Oligonucleotide inhibition of protein kinase C

Details Oligonucleotide inhibition of protein kinase C Oligonucleotide inhibition of protein kinase C

1995-06-07

1999-03-16

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435325, 435366, 536 231, 536 2431, 536 245, C12Q 168, C12N 1585, C07H 2104

Patent

active

058829270

ABSTRACT:
Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. In preferred embodiments, the oligonucleotides contain one or more chemical modifications. Methods of modulating PKC expression and of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression using oligonucleotides targeted to PKC are disclosed.

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