Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1997-04-04
1999-06-22
Elliott, George C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 514 44, 536 231, 536 232, 536 241, 536 245, C07H 2104, A61K 4800
Patent
active
059142693
ABSTRACT:
Compounds, compositions and methods are provided for inhibiting the expression of human EGFR. The compositions comprise oligonucleotides complementary to mRNA targeted to nucleic acids encoding EGFR. Methods of using these oligonucleotides for inhibition of EGFR expression and for treatment of diseases such as cancers associated with overexpression of EGFR are provided.
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Bennett C. Frank
Lipton Allan
Witters Lois M.
Elliott George C.
ISIS Pharmaceuticals Inc.
McGarry Sean
The Penn State Research Foundation
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