Oligonucleotide functionalizing reagents

Details Oligonucleotide functionalizing reagents Oligonucleotide functionalizing reagents

1987-10-02

1990-04-03

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

558168, 558169, 558171, 536 27, 552104, C07F 924, C07F 965

Patent

active

049142100

ABSTRACT:
Oligonucleotide functionalizing reagents are disclosed which are useful in introducing sulfhydryl, amino and additional hydroxyl groups into oligonucleotides. The reagents are substantially linear in structure, at one end provided with a phosphoramidite moiety, at an opposing end provided with a sulfhydryl, amino or hydroxyl moiety, the two ends linked through a hydrophilic spacer chain. Methods of using and synthesizing the novel reagents are disclosed as well.

REFERENCES:
patent: 4522735 (1985-06-01), Chasar
patent: 4582789 (1986-04-01), Sheldon, III et al.
patent: 4617261 (1986-10-01), Sheldon, III et al.
Greene, "Protective Groups in Organic Synthesis", pp. 34, 35, 72, 73, 201, 265.
Chem. Abst. 107(3):23650d.
Mitsunobu, Jan. 1981, Synthesis, pp. 1-28.

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