Oligonucleotide dimers with amide linkages replacing phosphodies

Details Oligonucleotide dimers with amide linkages replacing phosphodies Oligonucleotide dimers with amide linkages replacing phosphodies

1994-12-20

1997-09-02

LeGuyader, John L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 243, 536 256, C07H 1900, C07H 2100, C07H 2102, C07H 2104

Patent

active

056633122

ABSTRACT:
Disclosed are oligonucleotide analogs comprising oligonucleoside sequences having from 3 to about 200 bases and containing internucleoside linkages wherein amide linkages replace phosphodiester linkages that are the backbones of the natural oligonucleotides that make up RNA and DNA. Also disclosed are bifunctional nucleoside analogs, a process for preparing dimers and trimers therefrom, and a method of using these bifunctional nucleoside intermediates, including the dimers and trimers, to synthesize the above-described oligonucleotide analogs using conventional synthetic organic procedures known in the art, preferably in a solid phase synthesis, more preferably in an automated peptide synthesizer.

REFERENCES:
Gura "Antisense has growing pains" Science 270:575-577 Oct. 27, 1995.
Milligan et al. "Current concepts in Antisense drug design" J. Medicinal Chem. 36(14):1923-1927 Jul. 9, 1993.

Affiliated with

Also associated with

Rating

Oligonucleotide dimers with amide linkages replacing phosphodies does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oligonucleotide dimers with amide linkages replacing phosphodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oligonucleotide dimers with amide linkages replacing phosphodies will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-309474