Oligonucleotide derivatives and production thereof

Details Oligonucleotide derivatives and production thereof Oligonucleotide derivatives and production thereof

1987-02-20

1989-04-11

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 2104

Patent

active

048208124

ABSTRACT:
An oligonucleotide derivative having an amino group protected with an eliminatable group bonded through a phosphate group and a spacer with an appropriate length to the 5'-end of an oligonucleotide protected suitably at the 3'-hydroxyl group and the base moiety of the nucleotide, and an immobilized oligonucleotide derivative having a Sepharose carrier bonded to the amino group in place of said protective group are disclosed. Methods for production of these derivatives are also disclosed.

REFERENCES:
Arndt-Jovin et al., The Chemical Abstracts 83:54789w, (1975).
Chem. Reviews, vol. 77, No. 2, pp. 209-211, (1977), "Chem. Synthesis of Oligonucleotides."

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