Oligonucleotide derivatives and production thereof

Details Oligonucleotide derivatives and production thereof Oligonucleotide derivatives and production thereof

1986-04-25

1989-07-18

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435810, 935 78, C12A 168

Patent

active

048493368

ABSTRACT:
Biotin- or 2,4-dinitrophenyl-oligodeoxyribonucleotide derivative represented by the formula shown below and its preparation method is disclosed: ##STR1## wherein: R is ##STR2## m and n are each 0 or a natural number; R.sup.1 is a straight or branched hydrocarbon residue; and B is a base constituting the nucleotide (in which when a plural number of B exist, they may be either identical or different). This compound is useful for use as a nonradioactive affinity probe for nucleic acid or a primer.

REFERENCES:
Proc. Natl. Acad. Sci. U.S.A., vol. 78, No. 11, pp. 6633-6637, Nov. 1981, "Enzymatic Synthesis of Biotin-Labeled Polynucleotides: Novel Nucleic Acid Affinity Probes", Langer et al.
Nishimura et al., Chemical & Pharmaceutical Bulletin, (1980), 28, No. 6, pp. 1695-1703.
Smagowicz et al., Chemical Abstracts, (Jun. 8, 1981), 94, No. 23, p. 241, No. 187647x.
Smagowicz et al., Biochemistry, (Sep. 15, 1981), 20, No. 19, pp. 5538-5546.
Gumport et al., Nucleic Acids Synthesis: Applications to Moleuclar Biology and Genetic Engineering (1980), 7, pp. 167-171, IRL Press Ltd., London, GB.
Langer et al., Chemical Abstracts, (Feb. 15, 1982), 96, No. 7, p. 207, No. 47771z, Columbus, Ohio, U.S.
Vincent et al., Chemical Abstracts, (Feb. 28, 1983), 98, No. 9, Abstract No. 68363z, Columbus, Ohio, U.S.

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