Oligonucleotide compositions and their use to induce apoptosis

Details Oligonucleotide compositions and their use to induce apoptosis Oligonucleotide compositions and their use to induce apoptosis

2007-04-03

2007-04-03

McGarry, Sean (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024500, C514S04400A, C435S006120

Reexamination Certificate

active

10223672

ABSTRACT:
The present invention provides novel synthetic oligonucleotide sequences (hereinafter sequence) of 3 to 9 bases in length comprising one or more non-DNA bases wherein the bases are nebularine, hypoxanthine, or uracil, or combinations of nebularine, hypoxanthine and uracil bases. These sequences optionally further comprise one or more guanine bases or one or more thymine bases, or combinations thereof. The present invention also provides methods of using these compositions to induce responses in cells, and to treat diseases and conditions characterized by undesired cellular proliferation such as autoimmune disease, lymphoproliferative disease, inflammation or cancer.

REFERENCES:
patent: 5106727 (1992-04-01), Hartley et al.
patent: WO 9318187 (1993-09-01), None
Eritja et al. (1986) Nucleic Acids Res. 14:8135-8153.
Jiricny et al. (1986) Nucleic Acids Res. 14:6579-6590.
Bronwyn G. Hughes and Roland K. Robins; 2′,5′-Oligoadenylates and Related 2′,5′-Oligonucleotide Analogues. 2. Effect on Cellular Proliferation, Protein Synthesis, and Endoribonuclease Activity;Biochemistry(1983) 22, 2127-2135.
David Wang and John M. Essigmann; Kinetics of Oxidized Cytosine Repair by Endonuclease III ofEscherichia coli; Biochemistry(1997), 36, 8628-8633.
Ramon Eritja et al.; Synthesis and properties of oligonucleotides containing 2′-deoxynebularine and 2′-deoxyxanthosine;Nucleic Acids Research; (1986) vol. 14, No. 20; 8135-8153.
Dietmar Porschke; Thermodynamic and Kinetic Parameters of Oligonucleotide—Oligopeptide Interactions Specificity of Arginine inosine Association'Eur. J. Biochem; (1978) 86, 291-299.
Murat Saparbaev and Jacques Laval; Excision of hypoxanthine from DNA containing dIMP residues by theEscherichia coli, yeast, rat, and human alkylpurine;Proc. Natl. Acad. Sci. USA; (1994) vol. 91, p. 5873-5877.
Paula J. Bates et al.; Antiproliferative Activity of G-rich Oligonucleotides Correlates with Protein Binding;The Journal of Biological Chemistry; vol. 274, No. 37, Issue of Sep. 10, pp. 26369-26377, 1999.
Goberdhan P. Dimri et al.; A biomarker that identifies senescent human cells in culture and in aging skinin vitro; Proc. Natl. Acad. Sci. USA; vol. 92, pp. 9363-9367; Sep. 1995; Cell Biology.
M.C. Filion, Ph.D. et al.;Pro-apoptotic and terminal differentiation activity of a 6 base length phosphodiester oligonucleotide, Oligomodulator BT 99-25, towards leukemia cells.; (oral session 1092) Program and Abstracts of the 6thInternational Symposium held at L'Institut Pasteur, Paris, France; Feb. 9-12, 2002.
John E. Mata et al.; A Hexameric Phosphorothioate Oligonucleotide Telomerase Inhibitor Arrests Growth of Burkitt's Lymphoma Cellsin Vitroandin Vivo; Toxicology and Applied Pharmacology 144; pp. 189-197 (1997); Article No. TO978103.
Carla Morassutti et al.; Effect of Oligomer Length and Base Substitutions on the Cytotoxic Activity and Specific Nuclear Protein Recognition of GTn Oligonucleotides in the Human Leukemic CCRF-CEM Cell Line;Nucleosides&Nucleotides, 18(6&7), 1711-1716 (1999).
Martin Read et al.; Structure-based design of selective and potent G quadruplux-mediated telomerase inhibitors;PNAS, 4844-4849; Apr. 24, 2001, vol. 98, No. 9.
Bruna Scaggiante et al.; Human cancer cell lines growth inhibition by GTnoligodeoxyribonucleotides recognizing single-stranded DNA-binding proteins;Department of Biomedical Sciences and Technologies and Department of Bone Marrow Transplant, University of Udine, Italy, (Received Nov. 28, 1997)—EJB 97 1675/2.
Richard W. Wagner; Gene inhibition using antisense oligodeoxynucleotides;Nature International Weekly Journal of Science; vol. 372, No. 6504, Nov. 24, 1994; 333-335.
Valentin V. Vlassov et al.; Transport of oligonucleotides across natural and model membranes;Biochimica et Biophysica Acta; vol. 1197, No. 1, (1994) 95-108.

Affiliated with

Also associated with

Rating

Oligonucleotide compositions and their use to induce apoptosis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oligonucleotide compositions and their use to induce apoptosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oligonucleotide compositions and their use to induce apoptosis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3778376