Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1998-04-30
2000-04-11
Campbell, Eggerton A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 221, 536 231, C07H 2102, C07H 2104
Patent
active
06048974&
ABSTRACT:
Compounds referred to herein as oligonucleotide clamps are provided that stably bind to target polynucleotides in a sequence-specific manner. The oligonucleotide clamps comprise one or more oligonucleotide moieties capable of specifically binding to a target polynucleotide and one or more pairs of binding moieties covalently linked to the oligonudeotide moieties. In accordance with the invention, upon annealing of the oligonucleotide moieties to the target polynucleotide, the binding moieties of a pair are brought into juxtaposition so that they form a stable covalent or non-covalent inkage or complex. The interaction of the binding moieties of the one or more pairs effectively clamps the specifically annealed oligonucleotide moieties to the target polynucleotide.
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Gryaznov Sergei M.
Lloyd David H.
Campbell Eggerton A.
Lynx Therapeutics, Inc.
Macevicz Stephen C.
Powers Vincent M.
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