Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-12-27
1999-12-21
Kight, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 243, 536 231, 536 253, 536 251, 536 252, 514 44, 435 6, C07H 2102
Patent
active
060050942
ABSTRACT:
Acid resistant Oligomers suitable for oral administration, orally acceptable formulations of such Oligomers and preparation of pharmaceutical formations of such Oligomers are provided.
REFERENCES:
patent: 4839177 (1989-06-01), Colombo et al.
patent: 5135917 (1992-08-01), Burch
Agrawal et al., "Absorption, Tissue Distribution and In Vivo Stability in Rats of a Hybrid Antisense Oligonucleotide Following Oral Administration," Biochemical Pharmacology 50(4):571-576 (1995).
Agrawal, "Antisense oligonucleotides: towards clinical trials," TIBTECH 14:376-387 (Oct. 1996).
Agrawal et al., "Pharmacokinetics, biodistribution, and stability of oligodeoxyncleotide phosphorothioates in mice," Proc. Natl. Acad. Sci. USA 88:7595-7599 (Sep. 1991).
Bennett et al., "Cationic Lipids Enhance Cellular Uptake and Activity of Phosphorothioate Antisense Oligonucleotides," Molecular Pharmacology 41:1023-1033 (1992).
Bishop et al., "Phase I Trial of an antisense Oligonucleotide OL(1)p53 in Hematologic Malignancies," Journal of Clinical Oncology 14(4):1320-1326 (Apr. 1996).
Ts'o et al., "An Approach to Chemotherapy Based on Base Sequence Information and Nucleic Acid Chemistry," Biological Approaches to the Controlled Delivery of Drugs 507:220-241 (1987).
Webb et al., "BCL-2 antisense therapy in patients with non-Hodgkin lymphoma," The Lancet 349:1137-1141 (1997) (Apr. 19, 1997).
Krieg et al., "CpG Motifs in Bacterial DNA Trigger Direct B-Cell Activation," Nature, 374, 546-549 (Apr. 6, 1995).
Gura, "Antisense Has Growing Pains--Efforts to Develop Antisense Compounds as Therapies for Cancer, AIDS, and Other Diseases Have Encountered Some Unexpected Questions About How the Drugs Really Work," Science, 270, 575-577 (1995).
Havesi et al., "Contribution to the Mechanism of the Acid-Catalyzed Hydrolysis of Purine Nucleosides," J. Am. Chem. Soc., 94(13), 4715-4720 (1972).
Abstract of Nielsen et al.(I), Nature, 365, 566 (1993) entitled "`Peptide` nucleic acid hybridizes to complementary oligonucleotide," Chem. Eng. News, 71(41), 25 (Oct. 11, 1993).
Egholm et al., "PNA Hybridizes to Complementary Oligonucleotides Obeying the Watson-Crick Hydrogen Bonding Rules," Nature, 365, 566 (1993); original publication referred to in reference "S" supra.
R. S. Root-Bernstein(I), "AIDS Is More Than HIV: Part I," Genetic Engineering News, Sep. 1, 1992, pp. 4-6.
R. S. Root-Bernstein(II), "AIDS Is More Than HIV: Part II," Genetic Engineering News, Sep. 15, 1992, pp. 4-5.
Nielsen et al.(II), "Sequence Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polymide," Science, 254, 1497-1500 (1991).
Zon, "Oligonucleotide Analogues as Potential Chemotherapeutic Agents," Pharmaceutical Research, 5(9), 539-549 (1988).
T. Beardsley, "Trends in Cancer Epidemiology--A War Not Won," Scientific American, 270(1), 130-138 (1994).
Miller Paul S.
Simon Lionel N.
T'so Paul O. P.
Crane L. Eric
Genta Incorporated
Kight John
The Johns Hopkins University
LandOfFree
Oligonucleotide analogues having improved stability at acid pH does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oligonucleotide analogues having improved stability at acid pH, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oligonucleotide analogues having improved stability at acid pH will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-506438