Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-06-02
1997-09-23
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 245, 536 256, 435 6, A61K 3170, C07H 2104
Patent
active
056704895
ABSTRACT:
A dinucleotide analogue of formula ##STR1## where B.sup.1 and B.sup.2 are each independently a monovalent nucleoside base radical;
REFERENCES:
patent: 5466677 (1995-11-01), Baxter et al.
Padyukova et al.(I), "A New Synthetic Route to Phosphonate Analogs of 5'-Nucleotides," Bioorg. Khim., 13(5), 706-707 (1987); Chem. Abstr., 108(19), p. 691, Abstr. No. 167857v ((1988).
Mikhailov et al., "Use of 5-Deoxy-ribo-hexofuranose Derivatives for the Preparation m of 5'-Nucleotide Phosphonates and Homoribonucleosides," Collect. Czech. Chem. Comm., 54, 1055-1066 (1989).
Padyukova et al.(II), "A New Scheme for the Synthesis of 5'-Nucleotide Phosphonate Analogs," Tett. Lett., 28(31), 3623-3626 (1987).
Breaker et al., "Synthesis and Properties of Adenosine Oligonucleotide Analogues Containing Methylene Groups in Place of Phosphodiester 5'-Oxygens," Biochemistry, 32(35), 9125-9128 (1993).
Marquez et al., "Thiazole-4-carboxamide Adenine Dinucleotide (TAD). Analogues Stable to Phosphodiesterase Hydrolysis," J. Med. Chem., 29(9), 1726-1731 (1986).
Buhr et al., "Methylenephosphonate Nucleoside Analogs and Oligonucleotide Analogs Made Therefrom," Chem. Abstr., 118(1), p. 780, Abstr. No. 7326z (1993); see patent reference `L` for the complete publication.
Baxter Anthony David
Baylis Eric Keith
Collingwood Stephen Paul
De Mesmaeker Alain
Schmit Chantal
Crane L. Eric
Dohmann George R.
Kight John
Novartis Corporation
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