Oligonucleotide analogs with novel linkages

Details Oligonucleotide analogs with novel linkages Oligonucleotide analogs with novel linkages

1990-07-30

1993-11-23

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, C07H 1900, C07H 2100

Patent

active

052645649

ABSTRACT:
Oligonucleotide analogs wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by an formacetal/ketal type linkage are resistant to nucleases and do not need to exhibit the diastereomerism characteristic of many other oligonucleotide analogs, and thus are capable of strong hybridization to target RNA or DNA. These oligonucleotide analogs are useful in therapies which modulate gene expression using "antisense" or other specifically binding oligomers.

REFERENCES:
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Tittensor, J. R., J. Chem. Soc. (Section C: Organic Chemistry) (1971) 15:2656-2662.
Sekine, M., and Nakanishi, T., J. Org. Chem. (1989) 54:5998-6000.
Samukov, V. V., and Ofitsrov, V. I., Chem. Abstracts (1983) 98:547 (abstract no. 161094x).
Veeneman, G. H. et al., Chem. Abstracts (1991) 114:699 (abstract no. 7074h).

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