Oligonucleotide analogs containing thioformacetal linkages

Details Oligonucleotide analogs containing thioformacetal linkages Oligonucleotide analogs containing thioformacetal linkages

1992-04-24

1996-02-27

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 2531, C07H 2104

Patent

active

054950090

ABSTRACT:
Modified oligomers containing at least one internucleoside linkage of the formula Y.sup.1 CX.sub.2 y.sup.2 wherein at least one of Y.sup.1 and Y.sup.2 is sulfur and the other is oxygen and wherein each X is the same or different and is a stabilizing substituent are disclosed. These oligomers show superior binding properties and are thus useful for binding target substances in analytical uses. Also disclosed are improved methods for synthesis of oligomers containing linkages of the general formula --YCX.sub.2 Y-- wherein each Y may be independently oxygen or sulfur.

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