Oligonucleotide analogs containing sulfur linkages

Details Oligonucleotide analogs containing sulfur linkages Oligonucleotide analogs containing sulfur linkages

1988-06-06

1993-06-01

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

544242, 544264, 544265, 544267, 544276, 536 2721, 536 272, 536 284, 536 285, 536 2853, C07H 1900, C07H 2100, C07D47300, C07C 1308

Patent

active

052161412

ABSTRACT:
Analogs of DNA containing sulfides, sulfoxides, and sulfones as linking groups between subunits capable of forming bonds with natural oligonucleotides are described. The analogs are lipophilic, stable to chemical degradation under a wide range of conditions and stable to enzymatic degradation in vivo.

REFERENCES:
patent: 3846402 (1974-11-01), Eckstein et al.
patent: 4415732 (1983-11-01), Caruthers et al.
patent: 4469863 (1984-09-01), Ts'o et al.
patent: 4808708 (1989-02-01), Yoshida et al.
patent: 4837311 (1989-06-01), Tam et al.
Kawai, S. H. 1988 Abstract No. 318 No. Amer. Meeting of the Amer. Chem. Soc.
Noronha-Blob et al. J. of Med. Chem. vol. 20, No. 3, 1977, pp. 356-359.
Seela et al. (1987) Nucleic Acids Research vol. 15, No. 7, pp. 3113-3129.
B. M. Trosst & D. P. Curran, "Chemoselective Oxidation of Sulfides to Sulfones", Tetrahedron Letters 22: 1287-1290 (1981).
Noronha-Blob et al., Journal of Medicinal Chemistry, vol. 20, pp. 356-359 (1977).
Mungall et al., Journal of Organic Chemistry, vol. 42, pp. 703-706 (1977).
DiMenna et al., Journal of Medicinal Chemistry, vol. 21, pp. 1073-1076 (1978).
Harnden et al., Tetrahedron Letters, vol. 26, pp. 4265-4268 (1985).
Pitha et al., Biochemistry, vol. 10, pp. 4595-4602 (1971).

Affiliated with

Also associated with

Rating

Oligonucleotide analogs containing sulfur linkages does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oligonucleotide analogs containing sulfur linkages, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oligonucleotide analogs containing sulfur linkages will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1815896