Oligonucleotide analogs containing sulfur linkages

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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544242, 544264, 544265, 544267, 544276, 536 2721, 536 272, 536 284, 536 285, 536 2853, C07H 1900, C07H 2100, C07D47300, C07C 1308

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active

052161412

ABSTRACT:
Analogs of DNA containing sulfides, sulfoxides, and sulfones as linking groups between subunits capable of forming bonds with natural oligonucleotides are described. The analogs are lipophilic, stable to chemical degradation under a wide range of conditions and stable to enzymatic degradation in vivo.

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