Oligonucleotide analogs capable of passive cell membrane permeat

Details Oligonucleotide analogs capable of passive cell membrane permeat Oligonucleotide analogs capable of passive cell membrane permeat

1992-04-14

1997-05-27

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 243, 536 245, C07H 2100, C07H 2102, C07H 2104, A61K 3170

Patent

active

056333609

ABSTRACT:
Oligonucleotides that are capable of passive diffusion across cell membranes are disclosed. These oligonucleotides contain at least two nucleotide residues and show a log distribution coefficient in octanol:water of about 0.0-2.5 and a solubility in water of at least 0.001 .mu.g/mL. In preferred embodiments, either at least 80% of the internucleotide linkages are non-ionic, or at least 80% of the bases contain lipophilic hydrocarbyl substitutions, or a combination of these sums to 80%. These oligonucleotides may be conjugated to label and used to visualize cells.

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