Oligonucleolotides having site specific chiral...

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C536S022100, C536S023100, C536S024300, C536S024310, C536S024320, C536S024330, C435S007200

Reissue Patent

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10925348

ABSTRACT:
Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5′, and the 3′-terminal internucleoside linkages are chirally Sp and internal internucleoside linkages are chirally Rp.

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