Oligomers which inhibit expression of collagen genes

Details Oligomers which inhibit expression of collagen genes Oligomers which inhibit expression of collagen genes

1997-02-18

1998-07-14

LeGuyader, John L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 435 6, 435 911, 4351721, 4351723, 4353201, 435325, 435366, C12Q 168, C07H 2104

Patent

active

057806110

ABSTRACT:
Oligomers which inhibit expression of a collagen gene are described. It is believed that each oligomer, when introduced into a cell, forms a transcription-inhibiting complex composed of the oligomer and the collagen-gene promoter region. The oligomer, preferably a phosphorothioate deoxyoligonucleotide, preferably binds in the antiparallel orientation to the polypurine strand of a polypurine-polypyrimidine region of the promoter region of a mammalian .alpha.1 (I) collagen gene.

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