Oligomers which inhibit expression of collagen genes

Details Oligomers which inhibit expression of collagen genes Oligomers which inhibit expression of collagen genes

1996-09-11

1998-09-15

LeGuyader, John I.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536241, 435 6, 435 911, 4351721, 4351723, 435325, 435353, C12Q 168, C12N 1585, C07H 2104

Patent

active

058080376

ABSTRACT:
Oligomers which inhibit expression of a collagen gene are described. It is believed that each oligomer, when introduced into a cell, forms a transcription-inhibiting complex composed of the oligomer and the collagen-gene promoter region. The oligomer, preferably a phosphorothioate deoxyoligonucleotide, preferably binds in the antiparallel orientation to the polypurine strand of a polypurine-polypyrimidine region of the promoter region of a mammalian .alpha.1(I) collagen gene.

REFERENCES:
Khillan et al. PNAS 91: 6288-6302 (1994).
Laptev et al. Biochemistry 33:11033-11039 (1994).
Colige et al. Biochemistry 32: 7-11 (1993).
Shi et al. Circulation 90: 944-951 (1994).
Gewirtz et al. PNAS 93: 3161-3163 (1996).
Rojanasakul Adv. Drug Delivery Reveiews 18: 115-131 (1996).
Stull et al. Phesm. Res. 12: 465-487 (1995).

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