Oligomeric ketone compounds

Details Oligomeric ketone compounds Oligomeric ketone compounds

2005-07-19

2009-02-03

Witherspoon, Sikarl A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S185000, C514S529000, C514S675000, C424S439000

Reexamination Certificate

active

07485743

ABSTRACT:
A novel keto8enic compound is provided having general: Formula R(OCH(CH3)CH2C(O))n—O-A wherein n is an integer of 3 to 10, A is the residue of a 3-keto alkan-1-ol and R is selected from the group consisting of H, C1-C6 alkyl and acetoacetyl- Preferred compounds are those wherein A is a residue is of 4-hydroxy-2 butanone. A particularly preferred compound is a 4-hydroxy-2-butanone ester of an R-3-hydroxybutyrate oligomer having general: Formula H(OCH(CH3)CH2C(O))n—O—CH2—CH2—(CO)—CH3Nutraceutical and pharmaceutical compositions are provided for use in treating one or more of acute trauma, hemorrhagic shock, neurodegeneration, diabetes, and epilepsy, stroke, head trauma, myocardial infraction, congestive heart failure, pulmonary failure, kidney failure, obesity depression, pain and impaired cognition.

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Sahoo, B; Bhattacharya, A.; Fu, H.Y.; Gao, W

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