Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-06-05
1998-03-10
Marschel, Ardin H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 6, 436501, 536 231, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 536 253, 514 44, 935 77, 935 78, C07H 2102, C07H 2104, C12Q 168
Patent
active
057262977
ABSTRACT:
Modified oligodeoxyribonucleotide 3'--NHP (O) (O.sup.-) O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these compounds form more stable duplexes than phosphodiesters with complementary DNA and particularly RNA strands. Further, the phosphoramidate analogs can also form stable triplexes with double-stranded DNA target, where under similar conditions parent phosphodiester compounds failed to do so.
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Chen Jer-Kang
Gryaznov Sergei M.
Schultz Ronald G.
Lynx Therapeutics, Inc.
Macevicz Stephen C.
Marschel Ardin H.
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