Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-09-22
1998-06-16
Elliott, George C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 536 241, C07H 2100, C07H 2104
Patent
active
057672644
ABSTRACT:
A 12 to 30 nucleotide-unit long oligonucleotide that comprises at least one 5-substituted uracil or cytosine, where the 5-substituent is a C.sub.3-6 n-alkyl, a vinyl, a butenyl, an ethynyl, or a C.sub.4-12 n-1-alkynyl, with the proviso that the uracil moiety may not be substituted with an n-alkyl or a C.sub.8-12 n-1-alkynyl.
REFERENCES:
patent: 5484908 (1996-01-01), Froehler et al.
Kim, S. "The Influence of oligodeoxyribonucleotide phosphorothioate pyrimidine strands on triplex tormation," FEBS vol. 314 (1) pp. 29-32 Dec. 1992.
Xodo, et al "Effect of 5-metlylcytosine on the stability of triple stranded DNA -a thermodynamic study," NAR vol. 19(20) 1991 pp. 5625-5631.
Froeitzer et al "0ligodeoxynucleotides containing C-5 Propyne Analogs of 2'-Deoxyuridine and 2' Deoxycytidine," Tetrahedron Letters. vol. 33(37) pp. 5307-5310 1992.
Ebinger Katalin
Fellegvari Iren
Otvos Laszlo
Ruff Eva
Sagi Gyula
Elliott George C.
M'Garry Sean
MTA Zozponti Kemiai Kutato Intezet
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