Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Reexamination Certificate
2007-10-23
2007-10-23
Hayes, Robert C. (Department: 1649)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
C435S007210, C424S093700
Reexamination Certificate
active
10406817
ABSTRACT:
This invention provides populations of neural cells bearing markers of glial cells, such as oligodendrocytes and their precursors. The populations are generated by differentiating pluripotent stem cells such as human embryonic stem cells under conditions that promote enrichment of cells with the desired phenotype or functional capability. Various combinations of differentiation factors and mitogens can be used to produce cell populations that are over 95% homogeneous in morphological appearance, and the expression of oligodendrocyte markers such as GalC. The cells are capable of forming myelin sheaths, and can be used therapeutically improve function of the central nervous system.
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Keirstead Hans S.
Nistor Gabriel I.
Bozicevic Field & Francis LLP
Francis Carol L.
Hayes Robert C.
Kolker Daniel
The Regents of the University of California
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