Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-11-14
1998-05-26
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 435 721, 435331, 436536, 436538, 5303882, G01N 3353, G01N 33567, G01N 33536, G01N 33537
Patent
active
057563004
ABSTRACT:
A protein consisting essentially of purified oligodendrocyte-specific protein or purified biologically active variants thereof, or a combination of purified oligodendrocyte-specific protein and biologically active variants thereof. A purified and isolated peptide having the sequence Ala-Lys-Tyr-Arg-Arg-Ala-Gln-Leu-Ala-Gly residues 115-124 of SEQ ID NO:2. A device for identifying an epitope region of a peptide, protein, or protein homologue of interest comprising a polypropylene membrane having a plurality of sequentially oriented peptide spots, each spot containing a peptide having an amino acid sequence where the amino acid sequences of the peptides on the peptide spots sequentially progress through the amino acid sequence of the peptide, protein, or protein homologue of interest. A method of diagnosing multiple sclerosis and a method of treating multiple sclerosis. A method of diagnosing a disease or condition, such as an autoimmune disease, the disease or condition having the clinical feature of antibody production against a peptide, protein, or protein homologue.
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Bronstein Jeff M.
Lallone Roger L.
Seitz Robert S.
Farah David A.
Hutzell Paula K.
Navarro Mark
Research Genetics, Inc.
University of California at Los Angeles
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