Oligodendrocyte determination genes and uses thereof

Details Oligodendrocyte determination genes and uses thereof Oligodendrocyte determination genes and uses thereof

2006-04-04

2010-06-08

Ulm, John D. (Department: 1649)

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

Introduction of a polynucleotide molecule into or...

C435S368000, C435S375000, C435S377000

Reexamination Certificate

active

07732206

ABSTRACT:
The invention relates to methods and reagents for promoting the differentiation of oligodendrocytes from stem cells, by co-activating the Olig genes and the Nkx2.2 genes, and the use of the differentiated oligodendrocytes thus obtained in treating diseases, such as Multiple Sclerosis (MS). The invention also relates to the use of OLPs and oligodendrocytes thus obtained for drug screening.

REFERENCES:
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