Oligo-heteropolysaccharides having a heparin-like activity metho

Details Oligo-heteropolysaccharides having a heparin-like activity metho Oligo-heteropolysaccharides having a heparin-like activity metho

1986-01-07

1988-07-12

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 54, A61K 31725

Patent

active

047570571

ABSTRACT:
A oligo-heteropolysaccharide is disclosed which is very active against thrombotic syndromes and is prepared starting from depolymerized heparin fractions wherein the active groups, more particularly the sulfuric groups have been reconstituted by reacting a heparin fraction with a mol wt from 2,000 to 5,000 with the sulfotrioxide of a nitrogeneous organic base such as pyridine and trimethylamine. The method of preparation is also disclosed.

REFERENCES:
patent: 2832766 (1952-04-01), Wolfrom
patent: 3585184 (1967-12-01), Wolfrom et al.
Hladovec et al-Experientia, vol. XIII/5, May 15, 1957, pp. 190 & 191.
Thrombosis Research, vol. 9, pp. 575-583, 1976; vol. 12, 257-271 (1978); vol. 12, pp. 27-36, 1977.
Biochimica et Biophysica Acta, 343 (1974), 324-329.
Proceedings of the Society for Experimental Biology and Medicine, 146, 504-508 (1974).

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