Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-08-07
2000-12-05
Schwartzman, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 911, 4353201, 435325, 536 231, 536 245, C12Q 168, C12N 1585, C12N 1563, C07H 2104
Patent
active
06156513&
ABSTRACT:
Oligomers which inhibit expression of a collagen gene are described. It is believed that each oligomer, when introduced into a cell, forms a transcription-inhibiting complex composed of the oligomer and the collagen-gene promoter region. The oligomer, preferably a phosphorothioate deoxyoligonucleotide or a ribonucleotide, preferably binds in the antiparallel orientation to the polypurine strand of a polypurine-polypyrimidine region of the promoter region of a mammalian .alpha.1(I) collagen gene.
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Guntaka Ramareddy V.
Kandala Jagannadhachari
Kovacs Attilla
Weber Karl T.
Guntaka Ramareddy V.
Schwartzman Robert A.
Wang Andrew
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