Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-11-24
1990-01-09
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142258, 514253, 544 45, 544375, 546222, A61K 31445, C07D21152
Patent
active
048928780
ABSTRACT:
The present invention relates to pharmaceutical compositions of novel oleic acid esters of wellknown neuroleptics and tranquillizers of the phenothiazine, thioxanthene and butyrophenone type containing an aliphatic hydroxy group, and which may be represented by the following general formula: ##STR1## wherein R represents the residue of a hydroxy group containing neuroleptic selected from phenothiazines, thioxanthenes and butyrophenones, as well as pharmaceutically acceptable acid additions salts thereof, which compositions take the form of injectable solutions or suspensions in propylene glycol dioleate (TS-RD-9), methyl oleate or ethyl oleate.
None of the esters of Formula I have been specifically described before but have only been broadly disclosed in the patent literature, and the esters as such, as well as a method of preparation of said esters, fall within the scope of the present invention.
REFERENCES:
patent: 3194733 (1965-07-01), Yale et al.
patent: 3350268 (1967-10-01), Yale et al.
patent: 3681346 (1972-08-01), Peterson et al.
patent: 4153694 (1979-05-01), Buus et al.
Bregnedal Peter
Jensen Klaus G.
H. Lundbeck A/S
Hueschen Gordon W.
Raymond Richard L.
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