Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1978-04-03
1979-12-25
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
4242484, 424250, 424274, A61K 2700, A61K 3140, A61K 31445, A61K 31495
Patent
active
041805836
ABSTRACT:
Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula ##STR1## wherein R and R.sup.1 each represent hydrogen; or R and R.sup.1 taken together form a second bond between the carbon atoms bearing R and R.sup.1 ; n is a positive whole integer of from 1 to 3; Y represents --CH.dbd.CH--, or ##STR2## with the proviso that when each of R and R.sup.1 represents hydrogen, Y represents --CH.dbd.CH, and when Y represents --CH.dbd.CH, n is equal to 1 or 2; and Z represents thienyl, phenyl, or substituted phenyl wherein the substituents on the substituted phenyl may be attached at the ortho, meta, or para positions of the phenyl ring and are selected from halogen, a straight or branched lower alkyl chain of from 1 to 4 carbon atoms, a lower alkoxy group of from 1 to 4 carbon atoms, di(lower)-alkylamino, or a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino, or N-(lower)-alkylpiperazino. Pharmaceutically acceptable acid addition salts and individual geometric isomers of compounds of the above formula are also included as a part of this invention.
REFERENCES:
patent: 2739968 (1956-03-01), Sperber et al.
patent: 3068237 (1962-12-01), Rorig
patent: 3423406 (1969-01-01), Mull et al.
patent: 3734924 (1973-05-01), Black et al.
patent: 3736331 (1973-05-01), Black et al.
patent: 3759928 (1973-09-01), Zirskovic
Goodman et al., "The Pharmacological Basis of Therapeutics", p. 638, (1970).
Carr Albert A.
Kinsolving C. Richard
Friedman Stanley J.
Hattan L. Ruth
Rauchfuss, Jr. George W.
Retter Eugene O.
Richardson-Merrell Inc.
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