Olefin-substituted long chain xanthine compounds

Details Olefin-substituted long chain xanthine compounds Olefin-substituted long chain xanthine compounds

1993-01-12

1994-10-11

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544267, 544272, 544273, A61K 3152, C07D47302

Patent

active

053547560

ABSTRACT:
There is disclosed compounds and pharmaceutical compositions having a xanthine core and one or two hydrocarbon side chains bonded to a ring nitrogen atom, wherein the hydrocarbon side chains are independently a straight chain hydrocarbon having at least one double bond in a carbon chain length of from about 4 to about 18 carbon atoms in length, wherein multiple double bonds are separated from each other by at least three carbon atoms, and wherein the hydrocarbon chain may be substituted by a hydroxyl, halo or dimethylamino group and/or interrupted by an oxygen atom. The compounds lower elevated levels of unsaturated, non-arachidonate phosphatidic acid (PA) and diacylglycerol (DAG) derived from said PA within seconds of the primary stimulus and their contact with cells. The modulatory effect depends on the nature of the target cell and the stimulus applied.

REFERENCES:
patent: 4755517 (1988-07-01), Bruns et al.
patent: 5082845 (1992-01-01), Wolf et al.
patent: 5109003 (1992-04-01), Tanaka et al.

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