Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2000-04-14
2002-09-10
Williamson, Michael A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C514S529000
Reexamination Certificate
active
06447790
ABSTRACT:
BACKGROUND OF THE INVENTION
1. [Technical Field of the Invention]
The present invention relates to an oily material composition which is characterized in containing (both of) the specific two kinds of esters of an N-long chain acyl neutral amino acid, or containing an amphipathic substance in addition to those esters, and also relates to a cosmetic composition or a dermal external agent composition which is characterized in containing both of the above-mentioned two kinds of esters of an N-long chain acyl neutral amino acid, or further containing an amphipathic substance in addition to those esters. More particularly, the present invention relates to an oily material composition which is characterized in containing two kinds of esters, i.e., an alkyl or alkenyl ester of an N-long chain acyl neutral amino acid where the alcoholic moiety is a branched-chain or a straight-chain saturated or unsaturated hydrocarbon group having 1-30 carbon atom(s), and a sterol ester of an N-long chain acyl neutral amino acid where the alcoholic moiety is a sterol residue, or further containing an amphipathic substance such as cholesterol in addition to those esters, and also relates to a cosmetic composition or a dermal external agent composition which is characterized in containing such two kinds of esters, or further containing an amphipathic substance such as cholesterol in addition to those esters.
2. [Prior Art]
Epidermal horny layer is an important organ which adjusts the evaporation of moisture from living body and protects the living body from various stimuli from outside. It has been known that the moisture in the epidermal horny layer is important so that the skin functions appropriately, and greatly contributes to moistening and softness of the skin. It has been known that, as the components for retaining the moisture in the horny layer, oil-soluble components in addition to the water-soluble ones such as NMF (natural moisturizing factor) play an important role. Thus, the oil-soluble components per se, besides an action of formation of oily film for suppressing the evaporation of moisture, retain the moisture to some extent (moisturizing property) whereby they have an action of retaining the moisture in the horny layer. It has been also known regarding the hair, that an appropriate amount of moisture is necessary for achieving a conditioning effect which is to maintain good health and gloss like in the case of the skin, and that oil-soluble components play an important role therefor.
Vaseline, lanolin and the like have been commonly used already as oily materials for cosmetics for the skin and the hair.
However, hydrocarbon oil itself such as vaseline has no action of retaining the moisture but it suppresses the evaporation of moisture mostly by formation of an oily membrane. Therefore, it has an excessive blocking property and there are disadvantages that it inhibits the normal physiological action of the skin and further that it gives stickiness, poor spreading (i.e., poor spreadability), poor compatibility, heavy touch, etc. during and after use. Lanolin which is commonly used as an oily agent having a moisturizing property, also has a blocking property since it suppresses the evaporation of moisture due to formation of an oily film like vaseline and, in addition, it has a disadvantage, like vaseline again, such as stickiness, poor spreading, poor compatibility, heavy touch, etc. during and after application. Accordingly, in order to eliminate such a disadvantage resulting from the blocking property, there has been a demand for the development of an oily material which forms an oily film having a moisture-evaporating property (moisture permeability) to some extent.
On the other hand, amino acid derivatives have been developed already as oily materials having a high safety. I.e., esters of N-long chain acyl neutral amino acids with higher alcohols having 12-30 carbon atoms and esters of N-long chain acyl acidic amino acids with higher alcohols having 8-22 carbon atoms are disclosed in Japanese Patent Publication (Kokoku) Nos. 12908/1979 and 12609/1981, respectively, as oily materials for skin and hair cosmetics and for external drugs.
However, because of the poor moisturizing property of the materials per se, there is a disadvantage that, when they are compounded with cosmetic compositions having a purpose of skin care and hair care, the moisturizing property of the resulting cosmetic compositions is poor. And their conditioning effect on the hair is insufficient as well.
In the meanwhile, an oily material having a sterol group has been developed as an oily material having a good moisturizing property. I.e., esters of fatty acids with sterols are disclosed in Japanese Patent Publication (Koukou) No. 23320/1984 and esters of N-long chain acyl neutral amino acids with sterols are disclosed in Japanese Patent Application Laid-Open (Kokai) No. 112514/1993.
However, although such esters having the sterol moiety improve the moisturizing property, there is a disadvantage that stickiness, poor spreading, poor compatibility, heavy touch, etc. during and after application result when they are compounded with cosmetics.
Further, there is a disclosure in Japanese Patent Application Laid-Open (Kokai) No. 275697/1995, of a mixture of an ester of an N-long chain acyl acidic amino acid with a sterol and an ester of an N-long chain acyl acidic amino acid with a higher alcohol having 8-22 carbon atoms as an oily material having a moisturizing property.
However, such an oily material is not always satisfactory due to the stickiness, poor spreading, poor compatibility, heavy touch, etc. during and after application of the resulting cosmetics when incorporated in a cosmetic composition.
To sum up, although lanolin, esters of fatty acids with cholesterol, esters of acyl acidic amino acids with cholesterol, etc. have been known already as oily agents (oily materials) having a moisturizing property, they have a disadvantage that they give unpleasant feel such as stickiness and heavy touch during use. Their moisturizing property is insufficient as well. There is an additional disadvantage in terms of the stability of cosmetic compositions and dermal external agent compositions in an emulsified state which are emulsions prepared by compounding with them.
SUMMARY OF THE INVENTION
[Problems to be Solved by the Invention]
Under the background of the prior art as mentioned hereinabove, it is an object of the present invention to provide an oily material composition having both high moisture-retaining property and high moisture permeability and also giving a good feel on use to a cosmetic composition or a dermal external agent composition when incorporated therein.
[Means for Solving the Problems]
The present inventors have carried out an intensive investigation for achieving such object and have found that an oily material composition composed of the two specific kinds of esters of N-long chain acyl neutral amino acids per se has both good moisture-retaining and good moisture-permeating properties as well as good feel on use (poor stickiness, good spreading, good compatibility and poor heavy touch), that it gives moisture-retaining and moisture-permeating properties as well as good feel upon use, to a cosmetic composition and a dermal external agent composition when it is incorporated therein and further that the above oily material composition, when compounded with an amphipathic substance such as cholesterol, can significantly improve the cosmetic composition and the dermal external agent composition in moisturizing property and water incorporating property. On the basis of such findings, the present inventors have accomplished the present invention.
Incidentally, water incorporating property stands for a property of incorporation of water by an oil-soluble substance as noted in lanolin and that can be an index of moisturizing property and emulsion stability. As mentioned already, vaseline and the like form an oily film (membrane) having a blocking property, have no affi
Funakubo Toshihiko
Ichikawa Tomomichi
Ishii Hiroji
Koyama Masako
Ajinomoto Co. Inc.
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Williamson Michael A.
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