Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
1998-02-24
2001-02-27
Page, Thurman K. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S400000, C514S165000, C514S276000, C514S775000, C514S774000, C514S474000
Reexamination Certificate
active
06193986
ABSTRACT:
BACKGROUND OF THE INVENTION
The present invention relates to an oily composition and a process for producing it. In particular, the present invention relates to an oily composition excellent in storability and a process for producing it. The oily composition of the present invention is usable in the fields of foods, feeds, cosmetics, medicines, agricultural chemicals, machines and various industrial fields, taking advantage of excellent stability thereof.
An effective substance can be dispersed in an oil by directly adding the effective substance to the oil containing an emulsifier dissolved therein and mixing them. However, in this process, it is difficult to homogeneously disperse the effective substance in the oil phase to obtain a stable dispersion because this substance is immediately coagulated and precipitated. There is usually employed a process wherein an aqueous phase containing the effective substance dissolved therein is mixed with an oil phase to obtain a water-in-oil emulsion composition. The water-in-oil type emulsion compositions wherein the aqueous phase contains some substance, which were proposed hitherto, include a W/O-type emulsion containing an antioxidizing substance difficultly soluble in oils and fats and/or a synergist [Japanese Patent Publication for Opposition Purpose (hereinafter referred to as “J. P. KOKOKU”) No. Hei 4-64638], a W/O-type lipophilic antioxidant prepared by emulsifying a water-soluble antioxidizing substance [Japanese Patent Unexamined Published Application (hereinafter referred to as “J. P.
KOKAI” No. Sho 63-135483), a W/O-type emulsified composition containing an acid substance and/or a salt thereof (J. P. KOKAI No. Hei 6-343400), etc.
However, the purposes of using the above-described W/O type emulsified compositions in various fields were not completely attained because the aqueous phase is separated out or oiling off is caused during the storage by the influence of salts and acid substances contained in the aqueous phase even though no separation is caused immediately after the preparation of the compositions.
SUMMARY OF THE INVENTION
Therefore, an object of the present invention is to provide an oily composition having various advantages such as freeness from the precipitation of an effective substance in the course of the storage for a long period of time, an excellent storability, good masking of tastes, high thermal resistance, excellent controlling of dissolving out of water-soluble substances, high hygienic effect, exhibition of the antioxidizing function to an extent higher than that exhibited when the antioxidant is used as it is as the effective substance, and possibility of being used in combination with an oily antioxidant. Another object of the present invention is to provide a process for producing such an oily composition.
After intensive investigations, the inventors have found that the above-described objects of the present invention can be attained by an oily composition prepared by dispersing the effective substance in the form of a specified fine particles in an oil phase and limiting the water content of the solid phase and also the water content of the whole composition.
The present invention has been completed on the basis of the above-described finding. The present invention provides an oily composition composed of a solid phase comprising an effective substance selected from the group consisting of a water-soluble substance and water-dispersible substance and 50 to 4,000 parts by weight, for 100 parts by weight of the effective substance, of an ingredient selected from the group consisting of gelatin and gum arabic, and an oil phase comprising an oily component and an emulsifier, wherein the solid phase in the form of fine particles having an average particle diameter of not larger than 5 &mgr;m is dispersed in the oil phase, the water content of the solid phase is not higher than 30% by weight and the water content of the whole composition is not higher than 20% by weight.
The present invention also provides an oily composition composed of a solid phase comprising an effective substance selected from the group consisting of citric acid, common salt, sodium L-glutamate, sodium L-ascorbate, Aspirin, vitamin B., calcium chloride and casein calcium peptide, and 50 to 4,000 parts by weight, for 100 parts by weight of the effective substance, of an ingredient selected from the group consisting of gelatin and gum arabic, and an oil phase comprising an oily component selected from the group consisting of soybean oil, liquid paraffin, bees wax, squalane and fish oil, beef tallow, and an emulsifier, wherein the solid phase in the form of fine particles having an average particle diameter of 0.05 to 5 &mgr;m is dispersed in the oil phase, the water content of the solid phase is 0 to 30% by weight and the water content of the whole composition is 0 to 20% by weight.
The present invention also provides a process for producing an oily composition, which comprises heating an aqueous phase comprising an effective substance selected from the group consisting of a water-soluble substance and water-dispersible substance, an ingredient selected from the group consisting of gelatin and gum arabic and water to a dissolution temperature of the ingredient or higher, mixing the aqueous phase with an oil phase containing an oily component and an emulsifier to finally obtain a W/O-type emulsion and then dehydrating the emulsion to control the water content of the whole composition at 20% by weight or lower.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
The detailed description will be made on the oily composition of the present invention.
The oily composition of the present invention is composed of a solid phase comprising an effective substance selected from the group consisting of a water-soluble substance and water-dispersible substance, and an ingredient selected from the group consisting of gelatin and gum arabic, and an oil phase comprising an oily component and an emulsifier.
Examples of the effective substances usable in the present invention include sour seasonings, antioxidants, enzymes, bacteria, seasonings, inorganic salts, starches, amylolysis products, peptides, amino acids, dietary fibers, celluloses, nutrients, medicines, antibiotics, vaccines, insulin, and animal and vegetable extracts. In particular, they include citric acid and salts thereof, phosphoric acid and salts thereof, metaphosphoric acid and salts thereof, phospholipase, amylase, dehydrogenase, lactic acid bacteria, butyric acid bacteria, common salt, soy sauce, sodium carbonate, corn starch, dextrin, milk peptide, corn peptide, L-tryptophane, lysine chloride, sodium glutamate, polydextrose, microcrystalline cellulose, ascorbic acid and salts thereof, nicotinamide, magnesium L-ascorbyl phosphate, vitamin B's, niacin, calcium pantothenate, folic acid, biotin, calcium salts such as calcium chloride, milk minerals, calcium lactate, casein, calcium caseinate peptides, calcium phosphopeptide (CPP), KARUSHIUMU SAITORETOMATO (CCM), beef bone meal, shell powder, heme iron, arbutin, kojic acid, dipotassium glycyrrhizate, chlorpheniramine maleate, codeine phosphate, Aspirin, influenza vaccine, gymnema sylvestre extract, royal jelly, propolis, RAKANKA extract, herb extracts, grape extract, blueberry extract, rosemary extract, tea extract, cowberry extract, etc. These effective substances are used either alone or in combination of two or more of them. The amount of the effective substance is preferably 0.1 to 80% by weight, more preferably 1 to 70% by weight, based on the whole solid phase of the oily composition.
The term “gelatin” herein indicates polypeptides obtained from collagen contained in a high concentration in bones and skins of animals by extraction followed by purification and chemical and enzymatic decomposition. Those used in the fields of foods, feeds, cosmetics, medicines and industries are usable without any special limitation. Purified gelatin obtained by bleaching, purification, etc. is also usable.
The gum arabic used in the pr
Burns Doane , Swecker, Mathis LLP
Page Thurman K.
Seidleck Brian K.
The Nisshin Oil Mills Ltd.
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