Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1985-10-31
1986-11-18
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514912, A61K 31135
Patent
active
046236643
ABSTRACT:
An oil suspension, preferably sesame seed oil suspension, of the base form of phenylephrine as an opthalmic medicament. Surprisingly, the base form of phenylephrine is much quicker absorbed into the eye than the conventional acid salt form. As a result, lower dosage levels can be used to achieve the same mydriatic effect, thus reducing the risk of adverse side effects from systemic absorption.
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Handbook of Ocular Pharmacol., 2nd ed.--1978, p. 228, PSG Publishing Co., Inc.--Littleton, Mass.
Ocular Pharmacol., 4th ed.--1978, pp. 236-238, The C. V. Mosby Co.--Saint Louis.
Chem. Abst. 82: 116057(w) (1975)--Hardberger et al.
Chien Du-Shieng
Schoenwald Ronald D.
Robinson Douglas W.
University of Iowa Research Foundation
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