Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants
Patent
1995-05-17
1997-12-23
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Biocides; animal or insect repellents or attractants
424400, 514938, 514941, A61K 9107, A01N 2504
Patent
active
057004722
DESCRIPTION:
BRIEF SUMMARY
This application is a 35 USC 371 of PCT/EP93/03165 filed Nov. 11, 1993, published as WO94/10839 May 26, 1994.
The prior art already includes oil-in-water emulsions which contain active substances from the class of the phosphates and carbamates and which are employed in agriculture, in horticulture, in the domestic and hygiene sectors, and/or in the medical sector.
U.S. Pat. No. 4,107,302 discloses aqueous emulsion concentrates (EW) which, in addition to the organophosphorus active substance, for insecticidal control, and the surfactant, additionally and compulsorily contain an aqueous buffer solution for establishing a specific pH range.
EP-B-0 196 463 describes macroemulsions containing phosphates, in which nonionic nonylphenol/propylene oxide/ethylene oxide adducts are used to disperse the active substance.
The oil-in-water emulsions known from EP-B-0 062 181 contain, in addition to the active substances, as emulsifier at least one and generally two or more alkylaryl polyglycol ethers in a mixture with ionic alkylarylsulfonic acid salts.
EP-B-0 289 909 discloses aqueous, phase-stable, homogeneous emulsion compositions of organophosphorus pesticides, which contain, in addition to the active substance, a nonionic block copolymer, random copolymer, or random/block copolymer as surfactant and urea as a thickener and stabilizer.
EP-A-0 160 182 relates to aqueous microemulsions containing, in addition to a synthetic pyrethroid as active substance, an emulsifier mixture comprising calcium dodecylbenzenesulfonate, ethoxylated distyrylphenolammonium sulfate and ethoxylated tristyrylphenol.
In the emulsion concentrates (EC) described in GB-B-0 717 279 and U.S. Pat. No. 2,696,453, the quantity in which the active substances are dissolved in organic solvents (e.g. xylene, toluene, kerosene) and admixed with an emulsifier mixture comprising a nonionic and an ionic surfactant (polyoxyalkylene glycol/alkylarylsulfonate) ensures that, when these concentrates are diluted with water to the application concentration, a sufficiently stable aqueous emulsion is formed. On account of the solvents they contain, however, the concentrates are often associated with disadvantages in respect of their combustibility, toxicological characteristics, tolerance by plants and odor.
The abovementioned aqueous emulsifiable concentrates (EW) can only be prepared using additional auxiliaries, such as a thickener, stabilizer and buffer, organic solvents, and surfactant mixtures based mostly on nonionic and ionic surfactants.
Oil-in-water emulsions in the form of aqueous emulsifiable concentrates (EW) have now been found which, in addition to active substances from the class of phosphates and/or carbamates, and water, compulsorily contain at least one salt of an aryl polyglycol ether phosphate as ionic surfactant. In this case, the use of organic solvents, nonionic/ionic surfactant mixtures and/or additional auxiliaries, such as a thickener, stabilizer and buffer, is not compulsory.
It must be referred to as extremely surprising that the aqueous emulsifiable concentrates (EW) according to the invention are stable, since, on the basis of the known prior art, it was not to be expected that such emulsions, containing no thickener, stabilizer or buffer, little or no organic solvent and only one class of surfactant, are stable over a prolonged period.
The invention relates to oil-in-water emulsions comprising 0.001-70% by weight, preferably from 0.5 to 45% by weight, of at least one active substance from the class of the phosphates and/or carbamates, from 0,001-20% by weight, preferably from 0.1-10% by weight, of at least one salt of an aryl polyglycol ether phosphate of the formula I ##STR2## in which each R.sup.1, independently of the others, is hydrogen, C.sub.1 -C.sub.24 -alkyl, C.sub.5 -C.sub.15 -cycloalkyl, C.sub.6 -C.sub.24 -aryl or C.sub.6 -C.sub.24 -alkaryl, R.sup.2 is hydrogen, --O--C.sub.1 -C.sub.24 -alkyl, --O--C.sub.5 -C.sub.15 -cycloalkyl, --O--C.sub.6 -C.sub.18 -aryl or A, formula HN.sup..sym. (R.sup.3).sub.3, where each R.sup.3, inde
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Damo Zoltan
Frisch Gerhard
Hoechst Aktiengesellschaft
Page Thurman K.
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