Oil-in-water emulsions

Details Oil-in-water emulsions Oil-in-water emulsions

1993-04-26

1996-02-27

Ore, Dale R.

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Carboxylic acid ester

514844, 514847, 514938, A61K 912, A61K 4700

Patent

active

054949386

DESCRIPTION:

BRIEF SUMMARY
BACKGROUND OF THE INVENTION

1. Field of the Invention
This invention relates to storable oil-in-water emulsions, hereinafter referred to as o/w emulsions, containing alkyl glucosides and a partial glyceride with a monoglyceride content of 60 to 95% by weight and to emulsifier concentrates containing alkyl glucosides, a partial glyceride with a monoglyceride content of 60 to 95% by weight and a long-chain alcohol.
2. Statement of Related Art
The use of alkyl glucosides in the field of cosmetics is known from the literature. Thus, in their TRITON CG-110 pamphlet, Rohm & Haas recommend the use of an alkyl glucoside based on octanol/decanol (50:50) as an auxiliary emulsifier for cosmetic emulsions, for example for skin creams and lotions. Japanese patent application JP 89/203 036 (Shiseido) describes cosmetic emulsions containing a C.sub.8-24 glucoside together with a polyol containing at least three hydroxyl groups, for example glycerol, and an oil component. Finally, JP 86/5005 (Yoshitomi Pharm.) Ind. describes the use of alkyl (C.sub.8-18) glucosides as moisturizers, for example in cosmetic creams.
Alkyl glucosides are suitable as emulsifiers for the production of o/w emulsions. It has been found that the alkyl glucosides present in such emulsions have a pronounced tendency to crystallize which cannot be suppressed even by nonionic, anionic or cationic co-emulsifiers. Macroscopically, crystal growth is reflected in a deterioration in structure. Crystal structures such as these destroy the homogeneous droplet distribution which results in unwanted destabilization and, finally, in breaking of the emulsions. Accordingly, the problem addressed by the present invention was to provide storable o/w emulsions containing alkyl glucosides.


DESCRIPTION OF THE INVENTION

According to the invention, this problem has been solved by oil-in-water emulsions containing alkyl glucosides, characterized in that they contain general formula RO(G).sub.x, in which 95% by weight as crystallization inhibitor.
In one preferred embodiment of the invention, the emulsions according to the invention contain the water-insoluble oil (A) in a quantity of 5 to 30% by weight, the alkyl glucoside (B) in a quantity of 2 to 15% by weight and the fatty acid partial glyceride (C) in a quantity of 2 to 20% by weight.
The o/w emulsions according to the invention show no crystals of alkyl glucosides under a light microscope, even with 400x magnification. The emulsions are homogeneous and stable in storage.
Basically, any water-insoluble, linear or branched, physiologically safe aliphatic hydrocarbons, ethers or esters liquid at room temperature (20.degree. C.) may be used as the oil(s) (A). However, solid or relatively high melting paraffins, esters, waxes or fats may also be used.
Particularly suitable oils from the group of aliphatic hydrocarbons are, for example, squalane, squalene, dioctyl cyclohexane, Paraffinum perliquidum and Paraffinum subliquidum and isohexadecane (hydrogenated polybutylene).
Other particularly suitable oils are esters of trihydric and more than trihydric alcohols, more particularly vegetable triglycerides, for example olive oil, almond oil, peanut oil, sunflower oil, or even the esters of pentaerythritol, for example with pelargonic acid or oleic acid.
Other particularly suitable oils are monoesters and diesters corresponding to general formulae I, II and III group and R.sup.3 represents C.sub.2-16 alkylene groups. These monoesters and diesters contain at least 11 and at most 40 carbon atoms.
Oils of the mono and diester type corresponding to formulae (I), (II) and (III) are known as cosmetic and pharmaceutical oil components and as lubricant components. Among the monoesters and diesters of this type, the products liquid at room temperature (20.degree. C.) are the most important. Monoesters (I) suitable as oils are, for example, the isopropyl esters of C.sub.12-22 fatty acids such as, for example, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate. Other suitable monoesters are, for example, n

REFERENCES:
patent: 4400295 (1983-08-01), Ootsu et al.
patent: 4847078 (1989-07-01), Sheppard et al.
Chemical Abstracts, vol. 84, No. 7, Columbus; Ohio, US; Niiya, I et al.: "Effects of Emulsifiers on the Crystal Growth of Edible Solid Fats. IV. Effects of Propylene Glycol Esters of Fatty Acids and Unsaturated Fatty Acid Monoglycerides." (Abstract).
Triton CG-110 Technical Bulletin, Rohm & Haas, Philadelphia, Pa., May 1975.
A. J. O'Lenick, Jr., et al., "Guerbet Alcohols, A Versatile Hydrophobe", Soap Cosm. Chem. Spec., Apr., 1987, pp. 52, 54, 55, 115.

Affiliated with

Also associated with

Rating

Oil-in-water emulsions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oil-in-water emulsions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oil-in-water emulsions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1679657