Oil-in-water emulsion for parenteral administration

Details Oil-in-water emulsion for parenteral administration Oil-in-water emulsion for parenteral administration

1983-10-26

1986-01-07

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

514552, 514938, 514975, A61K 3578, A61K 3123

Patent

active

045633541

ABSTRACT:
An emulsifier adapted for use in a nutritive oil-in-water emulsion suitable for parenteral administration is produced by extracting vegetable lecithin with alkyl alcohols having from 1 to 3 carbon atoms, or mixtures thereof, followed by fractional precipitation at specific temperatures and concentrations effective to cause the removal of toxic materials. The alcohol soluble phospholipid fraction produced by the process contains an increased level of phosphatidyl choline and reduced levels of phosphatidyl ethanolamine, inositol phospholipids, phosphatidic acid and glycolipids.

REFERENCES:
patent: 1001247 (1911-08-01), Baer et al.
patent: 1667767 (1928-05-01), Bollmann
patent: 2727046 (1955-12-01), Scholfield et al.
patent: 2945869 (1960-07-01), Meyer et al.
patent: 2977283 (1961-03-01), Meyer et al.
patent: 3169094 (1965-02-01), Johannes
patent: 4101673 (1978-07-01), Chang
patent: 4235793 (1980-11-01), Betzing

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