Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1995-01-19
1997-03-18
Glass, Margaret W.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
424 707, 424 59, 252312, 252309, 514845, 514944, A61K 700
Patent
active
056120435
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to oil-in-water emulsions containing a perfluoropolyether, to their preparation, to cosmetic or dermatological compositions and to their use in the field of cosmetics and dermatology.
In the field of emulsions, those based on a liquid perfluoropolyether are known. They are, however, difficult to formulate. Indeed, perfluoropolyethers can only be made compatible with the usual cosmetic starting materials with difficulty: perfluoropolyethers are effectively insoluble in water and in many organic substances, apart from organic substances having a high fluorine content.
Numerous attempts have been made to overcome these difficulties. Thus, document EP-390206 describes an emulsion of liquid perfluoropolyethers in a hydrophilic medium where the hydrophilic phase consists essentially of a hydroxylated organic compound containing at least three hydroxyl units; the emulsion obtained then serves as a premix for the introduction of the perfluoropolyethers. This method is difficult to carry out insofar as it requires the production of a pre-emulsion into which the perfluoropolyether is introduced.
Moreover, document EP-494412 describes emulsions based on perfluoropolyethers and fatty substances; the stability thereof is provided by a polyol containing at least three hydroxyl functions, in an amount of greater than 10 %, and a surfactant which is soluble in the polyol. The difficulty therein also arises from the fact that the formulation is laborious to produce, because of the step for preparation of the pre-emulsion. Anhydrous or virtually anhydrous emulsions are prepared and water may then be added thereto.
Moreover, three-phase emulsions are described in particular in documents EP-360292, J63-107911 and EP-422984. The perfluoropolyether is, in these emulsions, dispersed in a water-in-oil or oil-in-water emulsion. Their preparation requires vigorous stirring, which allows the homogeneous dispersion of the perfluoropolyether(s) to be obtained. In these cases, suspension of the perfluoropolyethers in the three-phase system results, not in a thermodynamic phenomenon, but in a mechanical phenomenon; the stability of these systems is low insofar as the perfluoropolyether droplets, which are visible under a microscope, have a tendency to coalesce.
The non-homogeneous distribution of the oily perfluoropolyethers in the cosmetic preparations quite often results in a reduction in the performance of the oily perfluoropolyethers.
The Applicant has demonstrated a system which allows cosmetic emulsions containing oils of perfluoropolyether type to be stabilized in a simple manner, without involving a step for preparation of a pre-emulsion. They in fact contain, in one step, a certain amount of water when they are prepared. These emulsions according to the invention make it possible to use perfluoropolyethers, which are very useful in cosmetics for their protective film-forming and moisturizing effect, and in an effective minimum percentage, without the standard problems of homogeneity and stability arising, which problems have hitherto arisen when it has been desired to prepare a perfluoro oil/water emulsion directly.
The present invention relates to an oil-in-water emulsion containing at least one perfluoropolyether, a fluoro surfactant with the exclusion of cationic fluoro surfactants, a co-emulsifying agent, a fatty alcohol and a gelled aqueous phase.
The stable emulsion of perfluoropolyethers in water may be produced according to the invention by the stabilization which is produced by the presence of the four constituents, acting in synergy.
The Applicant has thus demonstrated that formulations prepared for comparison and using, besides the perfluoropolyether and water, only one, two or three of the components from among the gelling agent, the fluoro surfactant, the co-emulsifying agent and the alcohol did not lead to a fine and stable emulsion.
The emulsifying system according to the invention enables large amounts of perfluoropolyethers to be incorporated, relative to the amounts usually incorp
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Candau Didier
Deprez Sabine
"L'Oreal"
Glass Margaret W.
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