Oil adjuvant vaccine and method for preparing same

Details Oil adjuvant vaccine and method for preparing same Oil adjuvant vaccine and method for preparing same

1996-11-29

1998-09-29

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

4242831, 514937, 514938, 514939, 514943, A61K 4500, A61K 9107

Patent

active

058143211

ABSTRACT:
A water-in-oil type oil adjuvant vaccine comprises 20 to 90% by weight of an oil phase A) which is in a liquid state at ordinary temperature; 0.5 to 30% by weight of an emulsifying agent comprising a non-ionic surfactant B) which is a partial ester derived from a polyhydric alcohol carrying at least three hydroxyl groups and a fatty acid and which is in a liquid state at 40.degree. C. and a polyoxyethylene (20 to 60 moles) hydroxy fatty acid triglyceride C); and 5 to 75% by weight of an aqueous phase D) containing a biologically acceptable and effective amount of antigens, and optionally E) 0.01 to 10% by weight of an amino acid or a salt thereof and 0.01 to 10% by weight of a non-reducing sugar or a sugar alcohol having at least 5 hydroxyl groups in the molecule. In addition, a water-in-oil-in-water type oil adjuvant vaccine comprises the foregoing water-in-oil type oil adjuvant vaccine as an internal phase and an outer aqueous phase F) comprising 0.2 to 20% by weight of an emulsifying agent which comprises a non-ionic surfactant and which has an overall HLB value of not less than 10. The oil adjuvant vaccines show a high ability to induce an antibody-production over a long period of time and are excellent in requirements for medicines such as stability and safety.

REFERENCES:
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patent: 4647586 (1987-03-01), Mizushima et al.
patent: 4933179 (1990-06-01), Allison et al.
patent: 4985173 (1991-01-01), Takahashi et al.
patent: 5422109 (1995-06-01), Brancq et al.
patent: 5444041 (1995-08-01), Owen et al.
Journal of the Society of Cosmetic Chemists, pp. 311-326, William C. Grif, "Classification of Surface-Active Agents By `HLB`".

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