Radiant energy – Ionic separation or analysis – Methods
Reexamination Certificate
2005-12-20
2005-12-20
Lee, John R. (Department: 2881)
Radiant energy
Ionic separation or analysis
Methods
28, C435S004000, C435S006120, C436S043000, C436S086000, C436S094000, C436S173000, C436S174000
Reexamination Certificate
active
06977370
ABSTRACT:
Methods for producing a preponderance of gas phase ions having higher order charge states during laser desorption ionization of an analyte are presented, the methods comprising irradiating the analyte in the presence of energy absorbing molecules at a mid-IR wavelength that is offset from an IR absorption maximum of the energy absorbing molecules.
REFERENCES:
patent: 5045694 (1991-09-01), Beavis et al.
patent: 5118937 (1992-06-01), Hillencamp et al.
patent: 5719060 (1998-02-01), Hutchens et al.
patent: 6225047 (2001-05-01), Hutchens
patent: 6342393 (2002-01-01), Hofstadler et al.
patent: 6451616 (2002-09-01), Odom et al.
patent: 6558902 (2003-05-01), Hillenkamp
patent: 6656690 (2003-12-01), Crooke et al.
patent: 6683300 (2004-01-01), Doroshenko et al.
patent: 6706530 (2004-03-01), Hillenkamp
patent: 6723564 (2004-04-01), Hillenkamp
patent: 2002/0138208 (2002-09-01), Paulse et al.
patent: 2002/0193950 (2002-12-01), Gavin et al.
patent: 2003/0004402 (2003-01-01), Hitt et al.
patent: 2003/0032043 (2003-02-01), Pohl et al.
patent: 2003/0055615 (2003-03-01), Zhang et al.
patent: 2003/0124371 (2003-07-01), Um et al.
patent: 2003/0148528 (2003-08-01), Hillenkamp
patent: 2003/0207460 (2003-11-01), Kitagawa
patent: 2003/0228700 (2003-12-01), Peters et al.
patent: 2004/0007666 (2004-01-01), Griffey et al.
patent: 2004/0173740 (2004-09-01), McLuckey et al.
patent: WO 00/66265 (2000-11-01), None
patent: WO 00/67293 (2000-11-01), None
patent: WO 01/31580 (2001-05-01), None
J.W. Gauthier et al., “Sustained off-resonance irradiation for collision-activated dissociaton involving Fourier transform mass spectrormetry; Collision-activated dissociation technique . . . ”, Anal. Chim. Acta 246 (1991) 211-225.
Adam et al., “Serum Protein Fingerprinting Coupled with a Pattern-matching Algorithm Distinguishes Prostate Cancer from Benign Prostate Hyperplasia and Healthy Men,”Cancer Research, 62:3609-3614 (2002).
Ball et al., “An Integrated Approach Utilizing Artificial Neural Networks and SELDI Mass Spectrometry for the Classification of Human Tumours and Rapid Identification of Potential Biomarkers,”Bioinformatics, 18(3):395-404 (2002).
Jain, “Statistical Pattern Recognition: A Review”, IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 22, No. 1, Jan. 2000.
Li et al., “Proteomics and Bioinformatice Approaches for Identification of Serum Biomarkers to Detect Breast Cancer,”Clinical Chemistry Journal, 48:1296-1304 (2002).
Petricoin et al., “Use of Proteomic Patterns in Serum to Identify Ovarian Cancer,”The Lancet, 359:572-577 (2002).
Rai et al., “Proteomic Approaches to Tumor Marker Discovery; Identification of Biomarkers for Ovarian Cancer,”Archives of Pathology and Laboratory Medicine, 126:1518-1526 (2002).
Ciphergen Biosystems Inc.
Fish & Neave IP Group Ropes & Gray LLP
Haley Jr. James F.
Lee John R.
Shin Tae Bum
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