Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-12-23
1985-11-19
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
2602393T, 435120, A61K 31395, C07D27308, C12P 1714
Patent
active
045542899
ABSTRACT:
Compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts thereof wherein R.sup.1 is hydrogen, alkyl of 1 to 10 carbon atoms or acyl of 1 to 6 carbon atoms; R.sup.2 is hydrogen or halo; R.sup.3 is hydrogen, alkyl of 1 to 6 carbon atoms or acyl of 1 to 6 carbon atoms; R.sup.4 is hydrogen or alkyl of 1 to 6 carbon atoms; R.sup.5 is hydrogen or acyl of 1 to 6 carbon atoms; X is CONH.sub.2, hydroxyalkyl of 1 to 4 carbon atoms or COOR.sup.6 wherein R.sup.6 is hydrogen or alkyl of 1 to 4 carbon atoms; and Y is CONH.sub.2, hydroxyalkyl of 1 to 4 carbon atoms or COOR.sup.7 wherein R.sup.7 is hydrogen, alkyl of 1 to 10 carbon atoms or benzyl are useful for inhibiting the activity of amino-peptidase B, exhibit immunomodulating action against living organisms and exhibit anti-inflammatory activity.
REFERENCES:
patent: 4371533 (1983-02-01), Akimoto et al.
Enomoto Hiroshi
Ezure Yoji
Ikai Katsushige
Kuroda Hiroyuki
Nakamura Teruya
Bond Robert T.
Nippon Shinyaku Co. Ltd.
Takara Shuzo Co. Ltd.
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