Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1976-07-15
1977-11-08
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
128260, 424 16, 424 19, 424 22, 424 28, A61K 900, A61K 922
Patent
active
040576191
ABSTRACT:
An ocular therapeutic system for releasing a drug to the eye at a controlled and continuous rate for a prolonged period of time is disclosed. The system is shaped, sized and adapted for insertion and retention in the eye. The system contains an ophthalmically acceptable drug and it is formed of a polymeric material permeable to the passage of drug by diffusion. The material is an ethylene-vinyl ester copolymer of the general formula: ##STR1## WHEREIN R is hydrogen, alkyl of 2 to 7 carbons, or aryl, m is (4 to 80)% by weight and n is (100 - m)% by weight.
REFERENCES:
patent: 2200429 (1940-05-01), Perrin et al.
patent: 2396785 (1946-03-01), Hanford
patent: 2947735 (1960-08-01), Bartl
patent: 3710795 (1973-01-01), Higuchi et al.
patent: 3854480 (1974-12-01), Zaffaroni
Raff et al., Crystalline Olefin Polymers, Raff et al., part II, pp. 261-266 (1964).
Higuchi Takeru
Hussain Anwar
ALZA Corporation
Ciotti Thomas E.
Mandell Edward L.
Rose Shep K.
Sabatine Paul L.
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