Ocular scaffold for stem cell cultivation and methods of use

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

Reexamination Certificate

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C424S093700, C424S422000, C424S423000, C604S521000

Reexamination Certificate

active

07846467

ABSTRACT:
The present invention relates to a device and methods for culturing stem cells, and in particular, for culturing ocular stem cells and the use of stem cells cultured using the devices and methods of the invention for the treatment of diseases.

REFERENCES:
patent: 2005/0287223 (2005-12-01), Peyman
patent: WO 02/53193 (2002-07-01), None
Khor et al, “Preliminary study of a polycaprolactone membrane utilized as epidermal substrate” Journal of Materials Science: Materials in Medicine. (2003). vol. 14, pp. 113-120.
Lavik, E.B. et al. 2005 “Fabrication of degradable polymer scaffolds to direct the integration and differentiation of retinal progenitors”Biomaterials26:3187-3196.
Ang, L.P. and Tan, D.T.. 2004 “Ocular surface stem cells and disease: current concepts and clinical applications.”Ann Acad Med Singapore33:576-580.
Boulton, M. and Albon, J. 2004 “Stem cells in the eye.”Int J Biochem Cell Biol36:643-657.
Burman, S. et al. 2004 “Ophthalmic applications of preserved human amniotic membrane: a review of current indications.”Cell Tissue Bank5:161-75.
Daya, S.M. et al. 2005 “Outcomes and DNA analysis of ex vivo expanded stem cell allograft for ocular surface reconstruction.”Ophthalmology112:470-477.

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