Ocular microsphere delivery system

Details Ocular microsphere delivery system Ocular microsphere delivery system

1995-09-19

1998-11-17

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

424483, 424 7804, A61K 950

Patent

active

058372261

ABSTRACT:
A sustained release drug delivery composition and a method of making same are provided which comprises microspheres containing a pharmaceutically active agent, a core of a ion-exchange resin and a polymeric coating completely surrounding the core wherein the coating is water-insoluble and hydrolytically stable in physiological environments. The coating is non-erodible in physiological environments and is characterized by a diffusion constant suitable for the pharmaceutical agent to diffuse from the core to an aqueous environment at a predetermined release rate.

REFERENCES:
patent: 4847091 (1989-07-01), Illum
patent: 4931279 (1990-06-01), Bawa et al.
patent: 5288503 (1994-02-01), Wood et al.

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