Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1974-11-14
1976-10-12
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
A61K 3118
Patent
active
039858979
ABSTRACT:
Dextrorotatory stereoisomers of beta-adrenergic stimulatory phenethanolamines such as isoproterenol, soterenol, salbutamol, carbuterol, terbutaline, and metaproterenol lower normal or elevated intraocular pressure when topically administered to the eye. Reduction in intraocular pressure is of particular importance in the treatment of glaucoma, a disease marked by ocular hypertension. The dextrorotatory phenethanolamine compounds employed in the process of the present invention are notable for the low order of adrenergic activity in contrast to levorotatory and racemic stereoisomeric forms which are very potent beta-adrenergic stimulatory agents. Consequently, those side effects generally associated with adrenergic activation such as tachycardia, mydriasis, hypertension and hypotension are absent.
REFERENCES:
patent: 3618604 (1971-11-01), Ness
patent: 3660487 (1972-05-01), Larsen et al.
New Drugs, 1966 Ed., pp. 327-330.
Chem. Abstr. vol. 65, (1966) 2837; vol. 71 (1969) 59474b; vol. 74 (1971), 123505d.
Dungan Kendrick W.
Seidehamel Richard J.
Carnahan R. E.
Mead Johnson & Company
Uloth R. H.
Waddell Frederick E.
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