Ocular hypotensive agents

Details Ocular hypotensive agents Ocular hypotensive agents

1992-10-22

1993-12-28

Fay, Zohreh A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514247, 514913, A61K 3153, A61K 3150

Patent

active

052739767

ABSTRACT:
Pharmaceutical compositions and methods for treatment of eye disorders employ ocular hypotensive compounds of the formula (I) ##STR1## wherein R.sup.1 is selected from hydrogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy; each R.sup.2 is selected from hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, nitro or carboxy; R.sup.3 is selected from amino, mono-substituted amino, and di-substituted amino; A and B each represents C.sub.1 -C.sub.6 alkylene, X represents --NH-- or --CH.sub.2 -- and n is 1, 2 or 3; and pharmaceutically acceptable salts or esters thereof.

REFERENCES:
patent: 4011321 (1977-03-01), Coates et al.
patent: 4885293 (1989-12-01), Andrews et al.
patent: 4898862 (1990-02-01), Morisawa et al.
patent: 4914093 (1990-04-01), Morisawa et al.
The Merck Index, Eleventh Edition (1989), p. 1488.
Goth, Medical Pharmacology, pp. 181-183, 1984.

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