Ocular hypotensive agents

Details Ocular hypotensive agents Ocular hypotensive agents

1990-11-19

1993-03-16

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

514451, 514530, 514573, 514913, A61K 31695, A61K 3135, A61K 31215, A61K 3119

Patent

active

051944294

ABSTRACT:
The present invention relates to an ocular hypotensive composition and a composition for treatment of glaucoma which comprising an amount of 20-substituted-PGs or 20-substituted-15-keto-PGs effective as an ocular hypotensive agent; these compounds exhibit no or little side effects such as transient ocular hypertensive response, hyperemia of conjunctiva or of iris, dacryops, lema, closed eye and the like.

REFERENCES:
patent: 4128713 (1978-12-01), Schneider et al.
patent: 4131738 (1978-12-01), Smith
patent: 4599353 (1986-07-01), Bito
patent: 4883819 (1989-11-01), Bito
Woodward. Opthalmic Res 21 428 (1989).
Acta Pharmaceutica Sinica, vol. 16, No. 5 (May 1981).
Invest. Opthalmol. Visual Sci., vol. 16, No. 12, Dec. 1977, pp. 1125-1134.

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