Ocular gene therapy

Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses

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Details

4351723, 4353201, 514 44, 935 55, 935 56, 935 57, C12N 1500, A61K 4800

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active

058277021

ABSTRACT:
The invention relates to methods of ocular gene therapy.

REFERENCES:
Bennett, J., et al., "Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy", Nature Medicine, 2(6):649-654 (1996).
Roth, J.A., et al., "Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer", Nature Medicine, 2(9):985-991 (1996).
Marshall, E. "Gene Therapy's Growing Pains", Science 269: 1050-1055 (1995).
Jomary, C. et al. "Adenovirus-mediated gene transfer to murine retinal cells in vitro and in vivo", FEBS Letters 347: 117-122 (1994).
Thompson, H. W. et al. "High levels of in vivo gene transfer to corneal epithelium and endothelium", Invest. Opthal, Vis. Sci. 4: 1383 (1994).
Miller et al., FASEB J., 9:190-199, 1995.
Culver et al., Trends in Genetics, 10(5): 174-178, 1994.
Hodgson, Exp. Opin. Ther. Pat., 5(5):459-468, 1995.
Bennett, Jean, et al., "Adenovirus Vector-Mediated In Vivo Gene Transfer Into Adult Murine Retina", Investigative Ophthalmology & Visual Science, 35(5):2535-2542 (1994).
Zack, Donald J., "Ocular Gene Therapy", Arch Ophthalmology, 111:1477-1479 (1993).
Travis, G. H., et al., "Complete Rescue of Photoreceptor Dysplasia and Degeneration in Transgenic retinal degeneration slow (rds) Mice", Neutron, 9:113-119 (1992).
Li, T, et al., "In Vivo Transfer of a Reporter Gene to the Retina Mediated by an Adenoviral Vector", Investigative Ophthalmology & Visual Science, 335(5):2543-2547 (1994).
Bok, Dean, "Retinal Transplantation and Gene Therapy", Investigative Ophthalmology & Visual Sciences, 34(3) "473-476 (1993).
"Control of Gene Expression, Gene Transfer and Differential Display in the Eye-Poster Presentation, Sarasota Visual Art Center", Investigative Ophthalmology & Visual Sciences, 35(4):1705 (1994).
Lem, Janis et al., "Retinal degeneration is rescued in transgenic rd mice by expression of the cGMP phosphodiesterase .beta. subunit," Proc. Natl. Acad. Sci. USA, 89:4422-4426 (1992).
Nih "Report and Recommendations . . . ", Orkin et al. Dec. 7, 1995, 1-40.
LaFont et al., Lancet 346:1442-1443, 1995.

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