Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Reexamination Certificate
2005-02-01
2005-02-01
Hartley, Michael G. (Department: 1616)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
C424S009600, C424S009610, C600S317000
Reexamination Certificate
active
06849249
ABSTRACT:
The invention features a method of diagnosing or providing a prognosis regarding the state of Alzheimer's Disease in a mammal by contacting an ocular tissue with a detectably-labeled compound, which binds to an amyloid protein. An increase in binding of the compound to the ocular tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.
REFERENCES:
patent: 5171846 (1992-12-01), Gupta
patent: 6001331 (1999-12-01), Caprathe et al.
patent: 6013034 (2000-01-01), Fernandes Da Cunha Vaz et al.
patent: 6054114 (2000-04-01), Lansbury, Jr. et al.
patent: 6114175 (2000-09-01), Klunk et al.
patent: 6133259 (2000-10-01), Klunk et al.
patent: 6168776 (2001-01-01), Klunk et al.
patent: 6198532 (2001-03-01), Cabib et al.
patent: 6329531 (2001-12-01), Turner et al.
patent: 6423270 (2002-07-01), Wall
patent: 6600017 (2003-07-01), Glabe et al.
patent: 20020091321 (2002-07-01), Goldstein et al.
patent: 20020098153 (2002-07-01), Allen et al.
patent: 9822146 (1998-05-01), None
Frederikse, PH,Amyloid-like protein structure in mammalian ocular lenses, Curr. Eye Res. 20(6):462-468, 2000.
Klunk et al.,Development of small molecule probes fro the beta-amyloid protein of Alzheimer's disease, Neurobiol. Aging 15(6):691-698, 1994.
Link et al.,Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensative amyloid dye, X-34, Neurobiol Aging 22(2):217-226, 2001.
Pettergrew et al.,Clinical and neurochemical effects of acetyl-L-Canitine in Alzheimer's disease,_Neurobiol. Aging 16(1):1-4, 1995.
Selkoe, DJ,Toward a comprehensive tehory for Alzheimer's disease. Hypothesis: Alzheimer's Disease is caused by the cerebral acculmulation and cytotoxicity of amyloid β-Protein, Annal. N.Y. Acad. Sci. 924:17-25, 2000.
Skovronsky et al.,In Vivo detection of amyloid plaques in a mouse model of Alzheimer's diesease, Proc. Natl. Acad. Sci. USA 97(13): 7609-7614.
Siik et al.,autoflourescense in cataracious human lens and its relationship to ligth scatter, Acta. Ophthamol. (Cophen) 71(3):388-392; 1993.
Siik et al.,Influence of lens autoflourenscense on retinal nerve fiber layer evaluation, Acta. Ophthamol. Scand., 75(5):524-527, 1997.
Siik et al.,Lens autoflourescence and light scatter in relation to the lens opacities classification system LOCS III, Acta Ophthamol. Scand. 77(5):509-514, 1999.
Siik et al,Lens autoflourescence in ehalthy individuals, Acta. Ophtamol. (Copenh) 69(2):187-192, 1991.
Siik et al,Light scatter and cateratous human lense, Acta. Ophthamol. (Copenh) 70(3):383-388, 1992.
Styren et al.,X-34, a florescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology, J. Histochem. Cytochem 48(9): 1223-1232, 2002.
Kauffman et al.,Clinoquinol(Iodochlorhydroxyquin, Vioform)and Iodoquinol Diiodohydroxquin):Blindness and Neuropathy(RE9198), Pediatrics 86(5):797-798, 1990.
Bacskai, et al. (2002). J. Cereb Blood Flow &Metabol 22: 1035-1041.
Christie, et al. (2001) J Neurosci 21: 858-864.
Kung, et al. (2002). Brain Res 956: 202-210.
Kung, et al. (2002) J Mol Neurosci 19: 7-10.
Klunk, et al. (2001). Life Sci 69: 1471-1484.
Klunk, et al. (2002), J Neuropathol Exp Neurol 61: 797-805.
Klunk, et al. (2003). J Neurosci 23: 2086-2092.
Lee, Chi-Wan (2001). J Med Chem 44: 2270-2275.
Mathis, et al. (2002), Biorganic & Medic Chem Lett 12: 295-298.
McLellan, et al. (2003). J Neurosci 23: 2212-2217.
The International Search Report for PCT/ US 02/12945, mailed Dec. 12, 2002.
Helmuth, Laura (2002). Science 297: 752-753.
Lewis, Ricki (2002). The Scientist 16.
Burggren and Bookheimer (2002). Curr Top Medic Chem 2: 385-393.
Chylack, Jr. Leo T.
Goldstein Lee E.
Beattie Ingrid A.
Hartley Michael G.
Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
The Brigham and Women's Hospital, Inc.
The General Hospital Corporation
LandOfFree
Ocular diagnosis of Alzheimer's Disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ocular diagnosis of Alzheimer's Disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ocular diagnosis of Alzheimer's Disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3492836