Ocular cyclosporine composition

Details Ocular cyclosporine composition Ocular cyclosporine composition

1990-02-06

1995-05-02

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 514912, 514914, 530317, 530321, 424427, 424485, A61K 3702

Patent

active

054119529

ABSTRACT:
Cyclosporine compositions for topical ophthalmic use for treatment of immune disorders, to enhance or restore tear production, and to enhance or effect normal healing of the surface of the eye, containing cyclosporine dissolved in corn oil. The composition may further include antioxidants, lubricants, antibiotics, antifungals, antivirals, pilocarpine, vasoconstrictors, surfactants, wetting agents, anti-inflammatory agents (i.e. corticosteroids), preservatives, mucolytic agents (i.e. bromhexine, acetylcysteine), as well as other compounds.
The preferred composition is 2% cyclosporine, 1 mole % alpha tocopherol and 0.005% methyl paraben in corn oil.

REFERENCES:
patent: 4108985 (1978-08-01), Ruegger et al.
patent: 4117118 (1978-09-01), Harri et al.
patent: 4210581 (1980-07-01), Ruegger et al.
patent: 4215199 (1980-07-01), Harri et al.
patent: 4220641 (1980-09-01), Traber et al.
patent: 4288431 (1981-09-01), Traber et al.
patent: 4289851 (1981-09-01), Traber et al.
patent: 4384996 (1983-05-01), Bollinger et al.
patent: 4388307 (1983-06-01), Cavanak
patent: 4396542 (1983-08-01), Wenger
patent: 4554351 (1985-11-01), Wenger
patent: 4639434 (1987-11-01), Wenger et al.
patent: 4649047 (1987-03-01), Kaswan
patent: 4681754 (1987-07-01), Siegl
patent: 4703033 (1987-10-01), Seebach
patent: 4745100 (1988-05-01), Gilbard et al.
patent: 4923699 (1990-05-01), Kaufman
patent: 4963367 (1990-10-01), Ecanow
Hunter et al, Clin. Exp. Immunol., vol. 45, pp. 173-177, (1981).
Abelson, et al. Amer. J. Ophthal. 95, 500-505 (1983).
Abiose, et al. Annals of Ophthal. 15(8), 744-747, (1983).
Allansmith Clinical Ophthalmology, Chapter 9, vol. 4 pp 1-8 (Harper & Row 1986).
BenEzra, et al., Amer. J. Ophthal. 101, 278-282 (1986).
Grayson, Diseases of the Cornea pp. 334-367 (C. V. Mosby Co. 1983).
F. Hoffman and M. Wiederholt, Klin. Mbl. Augenheilk. 198, 92-95 (1985). (with translation).
Lemp, Clinical Ophthalmology vol. 4, pp. 1-10, Duane and Jaeger, editors (Harper & Row 1986).
Williams, et al., Transplantation 39(3), 242-244 (1985).
Williams, et al., British J. Ophthal 71, 239-242 (1987).
Kossendrup, et al., Cornea 4, 177-181 (1985).
Foets, et al., Brit. J. Ophthal. 69, 600-603 (1983).
Nussenblat, et al., Arch Ophthal. 103, 1559-1562 (1985).
Hoffmann, et al., Cornea 4, 3-7 (1985-1986).
Grisolano, et al., Ophthal. Surg. 17, 155-156 (1986).
Oh, et al., Invest. Ophthal. Vis. Sci. 26(4), 494-500 (1985).
Boisjoly, et al., Arch. Ophthalmol. 102. 1804-1807 (1984).
Hunter, et al., Clin. Exp. Immunol. 45, 173-177 (1981).
Singh, et al., Cornea 3, 272-277 (1985).
Klin., Mbl. Augenheik, 187(1985), Hoffmann, pp. 92-95.
Am. Journal of Ophthalmology 101, pp. 278-282, 1986, Ben Erza et al.

Affiliated with

Also associated with

Rating

Ocular cyclosporine composition does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ocular cyclosporine composition, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ocular cyclosporine composition will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1137160