Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1993-09-21
1997-04-15
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514178, A61K 3156
Patent
active
056209215
ABSTRACT:
The topical application to the ocular surface or adjacent regions of the eye of a preparation containing a therapeutic amount of an androgen or androgen analogue is disclosed as a method of relieving the chronic and acute manifestation of dry eye symptoms in Sj ogren's syndrome.
REFERENCES:
patent: 2861920 (1958-11-01), Dale et al.
patent: 3962430 (1976-06-01), O'Neill
patent: 4082881 (1978-04-01), Chen et al.
patent: 4154820 (1979-05-01), Simoons
patent: 4474751 (1984-10-01), Maslom et al.
patent: 4474811 (1984-10-01), Masuda et al.
patent: 4478818 (1984-10-01), Shell et al.
patent: 4581226 (1986-04-01), Dillon
patent: 4617299 (1986-10-01), Knepper
patent: 4642305 (1987-02-01), Johansson et al.
patent: 4774236 (1988-09-01), Cook et al.
patent: 4812448 (1989-03-01), Knopper
patent: 4861763 (1989-08-01), Cook et al.
patent: 4863912 (1989-09-01), Southren et al.
patent: 4866049 (1989-09-01), Maumenee et al.
patent: 4951683 (1990-08-01), Davis
patent: 4954490 (1990-09-01), Cook et al.
Holly, "Tear film physiology", Internat. Ophthalmol. Clin. 27:2-6 (1987).
Whitcher, "Clinical diagnosis of the dry eye", Internat. Ophthalmol. Clin. 27:7-24 (1987).
Lamberts, "Keratoconjunctivitis sicca", In The Cornea, Scientific Foundations and Clinical Practice (G. Smolin, and R.A. Theft, Eds.), pp. 293-308, Little, Brown and Co, Boston, MA (1983).
Sato et al., "Impact of Androgen Therapy in SJ ogren's Syndrome: Hormonal Influence on Lymphocyte Populations and to Expression in Lacrimal Glands of MRL/MP-Ipr/Ipr Mice", Invest. Ophthal. Vis. Sci 33: 193-201 (1992).
Sullivan et al., "Influence of Steroids and Immunosuppressive Compounds on Tear IgA levels in a Mouse Model of Sj ogren's Syndrome", Invest. Ophthal. Vis. Sci. 33: 845A (1992).
Sato et al., "Effect of Testosterone on the Lymphocyte Distribution in, and IgA Output of, Lacrimal Glands in a Mouse Model of Sj ogren's Syndrome", Invest. Ophthal. Vis. Sci. 32: 727A (1991).
Verheul et al., "Effects of Tibolone, Lynestrenol, Ethylestrenol, and Desogestrel on Autoimmune Disorders in NZB/W Mice," Clin. Immunol. Immunopathol. 38:198, 1986.
Jungers et al., "Hormonal Modulation in Systemic Lupus Erythematosus," Arthritis Rheum. 28:1243, 1985.
Lavalle et al., "Correlation study between prolactin and androgens in male patients with systemic lupus erythematosus," J. Rheumatol. 14:268, 1987.
Grossman, "Are there underlying immune-neuroendocrine interactions responsible for immunological sexual dimorphism?", Progress in NeuroEndocrinImmunology 3:75, 1990.
Sullivan et al., "Hormonal influence on the secretory immune system of the eye: endocrine impact on the lacrimal gland accumulation and secretion of IgA and IgG," J. Steroid Biochem. 34:253, 1989.
Schuurs et al., "Effect of gender and sex steroids on the immune response," J. Steroid. Biochem. 35:157, 1990.
Michalski et al., "Effect of androgen therapy on survival and suppressor cell activity in aged NZB/NZW F1 mice," Clin. exp. Immunol. 52:229, 1983.
Holdstock et al., "Effects of testosterone, oestradiol and progesterone on immune regulation," Clin. Exp. Immunol. 47:449, 1982.
Ahmed et al., "Effects of short-term administration of sex hormones on normal and autoimmune mice", J. Immunol. 134:204, 1985.
Morton et al., "Androgen Sensititive and autoimmune disease, I. Influence of sex and testosterone on the humoral immune response of autoimmune and non-autoimmune mouse strains to sheep erythrocytes," Immunology 44:661, 1981.
Brick et al., "Hormonal modulation of responses to thymus-independent and thymus-dependent antigens in autoimmune NZB/W-+/+ mice," J. Immunol. 134:3693, 1985.
Talal et al., "Interleukin 2, T. cell receptor and sex hormone studies in autoimmune mice", J. Rheum. (supl. 13) 14:21, 1987.
Sthoeger et al., "Regulation of the immune response by sex hormones. I. In vivo effects of estradiol and testosterone on pokeweed-mitogen-induced human B-cell differentiation," J. Immunol. 141:91, 1988.
Carlsten et al., "Oestradiol-and testosterone-mediated effects on the immune system in normal and autoimmune mice are genetically linked and inherited as dominant traits," Immunology 68:209, 1989.
Schuurs et al., "Experimental work with anabolics in autoimmunity models," Acta Endocrinol. (suppl). 271:97, 1985.
Appelmans, Arch. Ophthalmologie 81:577, 1948.
Bruckner, " Uber einen erfolgreich mit Perandren behandelten Fall von Sj ogren'schem Symptomenkomplex," Ophthalmologics 110:37, 1945.
Lebranchu et al., "Thymic function in NZB mice. IV. Role of thymus secretion and sex factors in the expression of suppression," Clin. Immunol. Immunopathol. 23:563, 1982.
Smith et al., "Autoimmunity-a perspective," Ann. Rev. Immunol. 1:175, 1983.
Talal et al., "Hormonal approaches to immunotherapy of autoimmune diseases," Ann. New York Acad. Sci. 475:320, 1986.
Eidenger et al., "Studies of the regulatory effects of the sex hormones on antibody formation and stem cell differentiation," J. Exp. Med. 136:1098, 1972.
Olsen et al., "Studies of immunological function in mice with defective androgen action. Distinction between alterations in immune function due to hormonal insensitivity and alteration due to other genetic factors," Immunology 73:52, 1991.
Savino et al., "Thymic hormone containing cells-IX. Steroids in vitro modulate thymulin secretion by human and murine thymic epithelial cells," J. Steroid Biochem. 30:479, 1988.
Weinstein et al., "Testosterone effect on bone marrow, thymus and suppressor T cells in the (NZB/NZW) F1 mice: its relevance to autoimmunity," J. Immunol. 126:41, 1980.
Kovacs et al., "Androgen receptors in human thymocytes," J. Immunol. 139:490, 1987.
Berczi et al., "Effects of hypophysectomy on immune function," In Psychonhuroimmunology II, Ader et al., eds., Academic Press, San Diego, CA, p. 339, 1990.
Berczi et al., "Neurohormonal-immune interaction." In Functional Endocrine Pathology, Kovaks et al., eds., Blackwell Scientific Publications, Inc., United Kingdom, p. 990, 1990.
Bartlett et al., "Development of autoimmunity in MRL/lpr mice and the effects of drugs on this murine disease", Scand. J. Rheumatol. Suppl. 75:290-299 (1988).
Wilson et al., Eds., "Williams Textbook of Endocinology," WB Saunders Company, Philadelphia (1985).
Knepper et al., "Effects of dexamethasone, progesterone, and testosterone on IOP and GaGs in the rabbit eye", Invest. Ophthalmol. Vis. Sci. 26:1093-1100 (1985).
Vida, "Androgens and Anabolic Agents," Academic Press, New York (1969).
Cavallero, "Relative effectiveness of various steroids in an androgen assay using the exorbital lacrimal gland of the castrated rat", Acta Endocrinol. (Copenh.), 55:119-131 (1967).
Lemp, "Recent developments in dry eye management", Ophthalmology 94:1299-1304 (1987).
Lubniewski et al., "Diagnosis and management of dry eye and ocular surface disorders", Ophthalmol. Clin. N.A. 3:575-594 (1990).
Kaswan, "Cyclosporine drops: a potential breakthrough for dry eye", Res. Prev. Blindness Writers Seminar, pp. 18-20 (1989).
Tabbara, "Sj ogren's Syndrome", In The Cornea, Scientific Foundations and Clinical Practice (G. Smolin, and R.A. Thoft, Eds), pp. 309-314, Little, Brown and Co. Boston, MA (1983).
Moutsopoulos et al., "Immunologic abnormalities in Sj ogren's syndrome", In Sj ogren's Syndrome. Clinical and Immunological Aspects (N, Talal, H.M. Moursopoulos, and S.S. Kassan, Eds. J. pp. 258-265, Springer Verlag, Berlin (1987).
Talal, et al., "Treatment of Sj ogren's syndrome", In Sj ogren's Syndrome, Clinical and Immunological Aspects (N. Talal, H.M. Moutsopoulos, and S.S. Kassan, Eds. 1, pp. 291-295, Springer Verlag, Berlin (1987).
Kincaid, "The eye in Sj ogren's Syndrome", In Sj ogren's Syndrome, Clinical and Immunological Aspects (N. Talal, H.M. Moutsopoulos, and S.S. Kassan, Eds. 1, pp. 25-33, Springer Verlag Berlin (1987).
Daniels, et al., "Diagnosis and differential diagnosis of Sj ogren's syndrome", In Sj ogren's Syndrome, Clinical and Immunological Aspects (N. Talal, H.M. Moutsopoulos, and S.S. Kassan, Eds. 1 pp. 193-199, Springer Verlag, Berlin (1987).
Daniels et al., "Histopathology of Sj ogren's syndrome", In Sj ogren's Syndrome, Clinical and Immun
Fay Zohreh
The Schepens Eye Research Institute, Inc.
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