Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-02-08
1995-12-12
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
530350, C07K 14705
Patent
active
054748984
ABSTRACT:
The present invention pertains in general to invertebrate octopamine receptor proteins and to polynucleotides encoding such receptors. The present invention also relates to insect for example, Drosophila octopamine receptors that are recombinantly expressed in mammalian cells where the receptor mediates the attenuation of adenylate cyclase activity and exhibits a pharmacological profile that is unique but closely related to mammalian adrenergic receptors. The present invention further relates to drug screening methods for the development of specific human pharmacological drugs and insecticides targeted for the octopamine receptor system.
REFERENCES:
Neuron 2:343-354, Mar. 1990, Arakawa et al Cloning, Localization and Permanent Expression of a Drosophila Octopamine Receptor.
EMBO J. 9(11): 3611-3617, No. 1990, Sandou et al. Cloning and Characterization of a Drosophila Tyramine Receptor.
J. Biol Chem. 264 (2): 11754-11761 (15 Ju. 1984) Fraser et al. Cloning, Sequence Analysis and Permanent Expression of a Human-.alpha..sub.2 Adrenergic Receptor in Chinese Hamster.
Axelrod, et al., "Octopamine", Nature, 265:501-504, 1977.
Battelle, et al., "Neurotransmitter Synthesis in Limulus Ventral Nerve Photoreceptors.sup.1 ", Experientia, 35/6:778-780, 1978.
Battelle, et al., "Targets of Octopamine Action in the Lobster: Cyclic Nucleotide Changes and Physiological Effects in Hemolymph Heart and Exoskeletal Muscle.sub.1 ", The Journal of Pharmacology and Experimental Therapeutics 205:2:438-448, 1978.
Blobel, et al., "Transfer of Proteins Across Membranes", The Journal of Cell Biology, 67:852-862, 1975.
Bodnaryk, "Identification of Specific Dopamine--and Octopamine-Senstive Adenylate Cyclases in the Brain of Mamestra Configurata WLK.", Insect Biochem., 9:155-162, 1979.
Bunzow, et al., "Cloning and Expression of a Rat D.sub.2 Dopamine Receptor cDNA", Nature, 336:783-787, 1988.
Casey, et al., "G Protein Involvement in Receptor-Effector Coupling", The Journal of Biological Chemistry, 263:6:2577-2580, 1988.
Chung, et al., "Cloning and Sequence Analysis of the Human Brain .beta.-Adrenergic Receptor", FEBS Lett., 211:2:200-206, 1987.
Chung, et al., "Site-Directed Mutagenesis and Continuous Expression of Human .beta.-Adrenergic Receptors", The Journal of Biological Chemistry, 263:9:4052-4055, 1988.
Cotecchia, et al., "Molecular Cloning and Expression of the cDNA for the Hamster .alpha..sub.1 -Adrenergic Receptor", Proc Natl. Acad. Sci. USA, 85:7159-7163, 1988.
Dao, et al., "Effect of Cyproheptadine on the Octopamine-Induced Responses in the Mammalian Central Nervous System.sup.1 ", Experientia, 36:584-585, 1980.
Dixon, et al., "Cloning of the Gene and cDNA for Mammalian .beta.-Adrenergic Receptor and Homology with Rhodopsin", Nature, 321:75-79, 1986.
Evans, "Multiple Receptor Types for Octopamine in the Locust", J.Physiol., 318:99-122, 1981.
Evans, "Phenyliminoimidazolidine Derivatives Activate both Octopamine.sub.1 and Octopamine.sub.2 Receptor Subtypes in Locust Skeletal Muscle", J. exp. Biol., 129:239-250, 1987.
Evans, et al., "Activities of Octopamine and Synephrine Stereoisomers on Octopaminergic Receptor Subtypes in Locust Skeletal Muscle", J. Pharm. Pharmacol., 40:855-861, 1988.
Fraser, et al., "SITE-Directed Mutagenesis of Human .beta.-Adrenergic Receptors: Substitution of Aspartic Acid-130 by Asparagine Produces a Receptor with High-Affinity Agonist Binding that is Uncoupled from Adenylate Cyclase", Proc. Natl. Acad. Sci. USA, 85:5478-5482, 1988.
Frielle, et al., "Cloning of the cDNA for the Human .beta..sub.1 -Adrenergic Receptor", Proc. Natl. Acad. Sci. USA, 84:7920-7924, 1987.
Gocayne, et al., "Primary Structure of Ray Cardiac .beta.-Adrenergic and Muscarinic Cholinergic Receptors Obtained by Automated DNA Sequence Analysis: Further Evidence for a Multigene Family", Proc. Natl. Acad. Sci. USA, 84:8296-8300, 1987.
Harmar, et al., "Octopamine-Sensitive Adenylate Cyclase in Cockroach Brain: Effects of Agonists, Antagonists, and Guaynylyl Nucleotides", Molecular Pharmacology, 13:512-520, 1976.
Harris-Warrick, et al., "Cellular Mechanisms for Modulation of Posture by Octopamine and Serotonin in the Lobster.sup.1 ", The Journal of Neuroscience, 4:8:1976-1993, 1984.
Hicks, et al., "Actions of Octopamine Upon Dorsal Horn Neurones of the Spinal Cord", Brain Research, 157:402-406, 1978.
Hicks, et al., "Comparison of the Actions of Octopamine and Catecholamines on Single Neurones of the Rat Cerebral Cortex", Br. J. Pharmac., 64:485-491, 1978.
Julis, et al., "Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor", Science, 241:558-564, 1988.
Konishi, et al., "The Physiological Properties of Amine-Containing Neurones in the Lobster Nervous System", J. Physiol., 279:215-229, 1978.
Kravitz, et al., "Amines and a Peptide as Neurohormones in Lobsters: Actions on Neuromuscular Preparations and Preliminary Behavioural Studies", J. exp. Biol., 89:159-175, 1980.
Livingstone, et al., "Biochemistry and Ultrastructure of Serotonergic Nerve Endings in the Lobster: Serotonin and Octopamine are Contained in Different Nerve Endings", Journal of Neurobiology, 12:1:27-54, 1981.
Lochrie, et al., "G Protein Multiplicity in Eukaryotic Signal Transduction Systems", Biochemistry, 27:14:4957-4965, 1988.
Nathanson, et al., "Octopamine-Sensitive Adenylate Cyclase: Evidence for a Biiological Role of Octopamine in Nervous Tissue", Science, 180:308-310, 1973.
Nathanson, et al., "Octopamine Receptors, Adenosine 3',5'-Monophosphate, and Neural Control of Firefly Flasing", Science, 203:65-68, 1979.
Onai et al., "Cloning, Sequence Analysis and Chromosome Localization of a Drosophila Muscarinic Acetylcholine Receptor", FEBS Lett., 255:2:219-255, 1989.
Regan, et al., "Cloning and Expression of a Human Kidney cDNA for an .alpha..sub.2 -Adrenergic Receptor Subtype", Proc. Natl. Acad. Sci. USA, 85:6301-6305, 1988.
Uzzan, et al., "Aminergic Receptors in Drosophila Melanogaster: Responsiveness of Adenylate Cyclase to Putative Neurotransmitters", Journal of Neurochemistry, 38:6:1542-1550, 1982.
Venter, et al., "Evolution of Neurotransmitter Receptor Systems", Progess in Neurobiology, 30:105-169, 1988.
Venter, et al., "Molecular Biology of Adrenergic and Muscarinic Cholinergic Receptors", Biochemical Pharmacology, 38:8:1197-1208, 1989.
Walker, et al., "The First Family (Adrenaline, Noradrenaline, Dopamine, Octopamine, Tyramine, Phenylethanolamine and Phenylethylamine)", Comp. Biochem. Physiol., 61C:261-266, 1978.
Yarden et al., "The Avian .beta.-Adrenergic Receptor: Primary Structure and Membrane Topology", Proc. Natl. Acad. Sci. USA, 83:6795-6799, 1986.
Fraser Claire M.
McCombie William R.
Venter John C.
The United States of America as represented by the Department of
Ulm John D.
Walsh Stephen G.
LandOfFree
Octopamine receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Octopamine receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Octopamine receptor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1359177