Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1983-02-16
1984-09-04
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, A61K 3700, C07C10352
Patent
active
044696795
ABSTRACT:
Certain octapeptides which have structures characterized by being a six unit cyclic peptide ring with a dipeptide tail have vasopressin antagonist activity. An important species of the group is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl-D-tyrosine)-4-valine-8-arginine-9-desglycine]vasopressin.
REFERENCES:
patent: 4367225 (1983-01-01), Manning et al.
patent: 4399125 (1983-08-01), Manning et al.
M. Manning et al., J. Med. Chem. 25 414-419 (1982).
M. Manning et al., J. Med. Chem. 25 45-50 (1982).
T. Barth et al., Collection Czechoslov. Chem. Commun. 39, 506 (1974).
B. Berde et al., Handb. Exp. Pharm. 23 860 (1968).
D. B. Hope et al., J. Biol. Chem., 237 (1963).
Huffman William F.
Moore Michael L.
Edgerton William H.
Foggio Richard D.
Lourie Alan D.
Phillips Delbert R.
SmithKline Beckman Corporation
LandOfFree
Octapeptide vasopressin antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Octapeptide vasopressin antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Octapeptide vasopressin antagonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1891813